1378391-42-4

Basic information

• Product Name: Velpatasvir intermediate
• Synonyms: VP N-4;(2S,4S)-2-(2-(9-bromo-8-oxo-8,9,10,11-tetrahydro-5H-dibenzo[c,g]chromen-3-yl)-2-oxoethyl) 1-tert-butyl 4-(methoxymethyl)pyrrolidine-1,2-dicarboxylate;(2S,4S)-4-(Methoxymethyl)-1,2-pyrrolidinedicarboxylic acid 2-[2-(9-bromo-8,9,10,11-tetrahydro-8-oxo-5H-benzo[d]naphtho[2,3-b]pyran-3-yl)-2-oxoethyl] 1-(1,1-dimethylethyl) ester;Product:Velpatasvir intermediate
• CAS NO: 1378391-42-4
• Molecular Formula: C₃₁H₃₄BrNO₈
• Molecular Weight: 628.50756
• EINECS: -0
• Mol File: 1378391-42-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Velpatasvir intermediate(CAS DataBase Reference)
• NIST Chemistry Reference: Velpatasvir intermediate(1378391-42-4)
• EPA Substance Registry System: Velpatasvir intermediate(1378391-42-4)

Safety Data

• Hazardous Substances Data: 1378391-42-4(Hazardous Substances Data)

Usage

Description

Velpatasvir intermediate is a critical chemical compound utilized in the synthesis of the antiviral drug velpatasvir, specifically designed to treat chronic hepatitis C virus infection. This intermediate serves as a fundamental building block in the intricate chemical process of fabricating the final drug, ensuring its potency, purity, and safety through adherence to stringent quality standards. The synthesis of this intermediate demands specialized equipment and profound expertise in organic chemistry, highlighting its indispensable role in the pharmaceutical industry's fight against hepatitis C.

Uses

Used in Pharmaceutical Industry:
Velpatasvir intermediate is used as a key component in the synthesis of velpatasvir for the treatment of chronic hepatitis C virus infection. Its role is pivotal in the manufacturing process, ensuring the drug's efficacy and safety.
Used in Antiviral Drug Production:
Velpatasvir intermediate is employed as a precursor in the production of antiviral medications, specifically targeting the development of velpatasvir. It contributes to the drug's formulation, which is aimed at combating the hepatitis C virus and improving patient outcomes.
Used in Quality Assurance Processes:
In the pharmaceutical industry, velpatasvir intermediate is used as a benchmark in quality assurance processes to guarantee the potency, purity, and safety of the final drug product. This ensures that the antiviral medication meets all regulatory standards and provides the desired therapeutic effects without compromising patient health.
Used in Research and Development:
Velpatasvir intermediate is also utilized in research and development initiatives within the pharmaceutical sector. It serves as a subject for further exploration and innovation, potentially leading to the discovery of new antiviral agents or improvements in existing treatments for hepatitis C and other viral infections.

Upstream product

• 1438383-92-6 3-acetyl-10,11-dihydro-5H-benzo[d]naphtho[2,3-b]pyran-8(9H)-one 
• 1438383-91-5 3-((trimethylsilyl)ethynyl)-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one 
• 1438383-90-4 9-bromo-3-(2-bromo-1-hydroxyethyl)-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one 
• 1378391-38-8 3-(2-bromo-1-hydroxyethyl)-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one 
• 1378388-16-9 (2S,4S)-N-(tert-butyloxycarbonyl)-4-(methoxymethyl)-pyrrolidine-2-carboxylic acid 
• 1438383-89-1 9-bromo-3-(2-bromoacetyl)-10,11-dihydro-5H-benzo[d]naphtho[2,3-b]pyran-8(9H)-one 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1378382-90-1 (2-bromo-5-iodobenzyloxy)(tert-butyl)dimethylsilane 
• 946525-30-0 4-bromo-3-hydroxymethyl-1-iodo-benzene 
• 1378388-20-5 3-chloro-10,11-dihydro-5H-benzo[d]naphtho[2,3-b]pyran-8(9H)-one 
• 66192-24-3 2-bromo-5-chlorobenzyl bromide 
• 22009-38-7 7-hydroxy-1-tetralone 
• 1378388-37-4 (2S,4S)-N-(tert-butyloxycarbonyl)-4-(methoxymethyl)-pyrrolidine-2-carboxylic acid methyl ester 
• 1378393-23-7 C₁₅H₂₃NO₈ 

Downstream Products

• 1378391-43-5 (2R,4R)-1-tert-butyl 2-(2-(9-((2S,5S)-1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)-5-methylpyrrolidine-2-carbonyloxy)-8-oxo-8,9,10,11-tetrahydro-5H-dibenzo[c,g]chromen-3-yl)-2-oxoethyl) 4-(methoxymethyl)pyrrolidine-1,2-dicarboxylate 
• 1378391-44-6 tert-butyl (2S,4S)-2-[5-(2-{(2S,5S)-1-[N-(methoxycarbonyl)-L-valyl]-5-methylpyrrolidin-2-yl}-1,4,5,11-tetrahydroisochromeno[4′,3′:6,7]naphtho[1,2-d]imidazol-9-yl)-1H-imidazol-2-yl]-4-(methoxymethyl)pyrrolidine-1-carboxylate 
• 1378391-45-7 tert-butyl (2S,4S)-2-[5-(2-{(2S,5S)-1-[N-(methoxycarbonyl)-L-valyl]-5-methylpyrrolidin-2-yl}-1,11-dihydroisochromeno[4′,3′:6,7]naphtho[1,2-d]imidazol-9-yl)-1H-imidazol-2-yl]-4-(methoxymethyl)pyrrolidine-1-carboxylate 
• 1377604-63-1 methyl {(1R)-2-[(2S,4S)-2-(5-{2-[(2S,5S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-5-methylpyrrolidin-2-yl]-1,4,5,11-tetrahydroisochromeno[4',3':6,7]naphtho[1,2-d]imidazol-9-yl}-1H-imidazol-2-yl)-4-(methoxymethyl)pyrrolidin-1-yl]-2-oxo-1-phenylethyl}carbamate 
• 1377049-84-7 methyl {(2S)-1-[(2S,5S)-2-(9-{2-[(2S,4S)-1-{(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetyl}-4-(methoxymethyl)pyrrolidin-2-yl]-1H-imidazol-5-yl}-1,11-dihydroisochromeno[4′,3′:6,7]naphtho[1,2-d]imidazol-2-yl)-5-methylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate 

Relevant articles and documents

PROCESSES FOR PREPARING ANTIVIRAL COMPOUNDS

The present disclosure provides processes for the preparation of a compound of formula: which is useful as an antiviral agent. The disclosure also provides compounds that are synthetic intermediates.

ANTIVIRAL COMPOUNDS

The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.