1379361-82-6Relevant articles and documents
COMPOUNDS AND COMPOSITIONS FOR TREATING DISEASE CONDITIONS ASSOCIATED WITH STING ACTIVITY
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Page/Page column 116; 117, (2022/01/24)
This disclosure relates to chemical entities (e.g., a compound or salt, and/or hydrate, and/or co-crystal, and/or drug combination of the compound pharmaceutically acceptable) that inhibit (e.g., antagonize) the interferon gene stimulator (STING). Such chemical entities are useful, for example, to treat a medical condition, disease or disorder in which increased (e.g. excessive) activation of STING (e.g. STING signalling) contributes to the pathology and/or symptoms and/or progression of the medical condition, disease or disorder (e.g. cancer) in a subject (for example, a human being). The invention also relates to compositions containing them, as well as methods of use and manufacture thereof.
MRGPRX2 ANTAGONISTS AND USES THEREOF
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Paragraph 00197-00198, (2021/05/15)
The present disclosure is directed to use of MrgprX2 antagonists in the treatment of inflammatory disorders, e.g., inflammatory disorders of the skin. This invention is also directed to pharmaceutical compositions comprising a MrgprX2 antagonist and a pharmaceutically or orally acceptable carrier for administration.
