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• 91-95-2 3,3',4,4'-tetraaminobiphenyl 
• 17696-62-7 Phenyl 4-hydroxybenzoate 
• 54998-28-6 ethyl 4-hydroxybenzenecarboximidoate hydrochloride 
• 123-08-0 4-hydroxy-benzaldehyde 
• 7411-49-6 3,3',4,4'-tetraaminobiphenyl tetrahydrochloride dihydrate 

Relevant academic research and scientific papers

Strong, specific, reversible binding ligands for transfer RNA: Comparison by fluorescence and NMR spectroscopies with distamycin binding for a new structural class of ligand

Binding data are presented for the interaction with brewer's yeast tRNA(Phe) of a new structural family of ligands, symmetrical bis- benzimidazoles. In addition specific perturbations in chemical shifts were detected by 1-dimensional NMR spectroscopy at 400 MHz for some imino and aromatic methyl protons of tRNA(Phe) when the tRNA was titrated with distamycin. Competitive displacement of the benzimidazole by added distamycin was followed fluorescence spectroscopy.

BIS-BENZIMIDAZOLE COMPOUNDS AND METHODS OF USING SAME

Provided herein are compounds and methods for modulating abnormal repeat expansions of gene sequences. More particularly, provided are inhibitors of RNA and the uses of such inhibitors in regulating nucleotide repeat expansions, e.g., to treat Myotonic Dystrophy Type 1 (DM1 ), Myotonic Dystrophy Type 2 (DM2), Fuchs dystrophy, Huntington Disease, Amyotrophic Lateral Sclerosis, or Frontotemporal Dementia.

ANTIBACTERIAL COMPOUNDS

Disclosed are compounds of formula (I), which are of use in the treatment of bacterial diseases and infections, to compositions containing those compounds and to methods of treating bacterial diseases and infections using the compounds. In particular, the compounds are useful for the treatment of infection with, and diseases caused by, Clostridium difficile.

New mustard-linked 2-aryl-bis-benzimidazoles with anti-proliferative activity

We describe new methodology for the synthesis of symmetric bis-benzimidazoles carrying 2-aryl moieties, including 2-[4-(3′- aminopropoxy)phenyl] and 2-[4-(3′-aminopropanamido)phenyl] substituents, together with the synthesis of novel hybrid molecules comprising bis-benzimidazoles in ester and amide combination with the N-mustard chlorambucil. The in vitro activities of these compounds against five cancer cell lines are also provided. The Royal Society of Chemistry 2006.

New developments in thermally stable polymers

Advances in high-temperature polymers since 1985 are discussed with the emphasis on the chemistry.High-temperature polymers refer to materials that exhibit glass-transition temperatures > 200 deg C and have the chemical structure expected to provide high thermooxidative stability.Specific polymers or series of polymers were selected to show how the chemical structure influences certain properties.Poly(arylene ethers) and polyimides are the two principal families of polymers discussed.Recent work on poly(arylene ethers) has concentrated on incorporating heterocyclic units within the polymer backbone.Recent polyimide work has centered on the synthesis of new polymers from novel monomers, several containing the trifluoromethyl group strategically located on the molecule.Various members in each of these polymer families display a unique combination of properties, heretofore unattainable.Other families of polymers are also briefly discussed with a polymer from an AB maleimidobenzocyclobutene exhibiting an especially attractive combination of properties.