Strong, specific, reversible binding ligands for transfer RNA: Comparison by fluorescence and NMR spectroscopies with distamycin binding for a new structural class of ligand

Article abstract of DOI:10.1080/07328319808004698

Binding data are presented for the interaction with brewer's yeast tRNA(Phe) of a new structural family of ligands, symmetrical bis- benzimidazoles. In addition specific perturbations in chemical shifts were detected by 1-dimensional NMR spectroscopy at 400 MHz for some imino and aromatic methyl protons of tRNA(Phe) when the tRNA was titrated with distamycin. Competitive displacement of the benzimidazole by added distamycin was followed fluorescence spectroscopy.

Full text of DOI:10.1080/07328319808004698

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Nucleosides and Nucleotides
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Strong, Specific, Reversible Binding
Ligands for Transfer Rna: Comparison By
Fluorescence and Nmr Spectroscopies
with Distamycin Binding for a New
Structural Class of Ligand
a
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Elena V. Bichenkova , Seyed E. Sadat-Ebrahimi , Amanda N.
a
a
a
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Wilton , Niamh O'Toole , Debora S. Marks & Kenneth T. Douglas
a
School of Pharmacy and Pharmaceutical Sciences, University of
Manchester Manchester, M13 9PL, U.K.
Version of record first published: 22 Aug 2006.
To cite this article: Elena V. Bichenkova , Seyed E. Sadat-Ebrahimi , Amanda N. Wilton , Niamh
O'Toole , Debora S. Marks & Kenneth T. Douglas (1998): Strong, Specific, Reversible Binding Ligands for
Transfer Rna: Comparison By Fluorescence and Nmr Spectroscopies with Distamycin Binding for a New
Structural Class of Ligand, Nucleosides and Nucleotides, 17:9-11, 1651-1665
To link to this article: http://dx.doi.org/10.1080/07328319808004698
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