1379610-86-2

Upstream product

• 353268-10-7 8-methoxy-4-phenyl-3,4,5,6-tetrahydrobenzo[h]quinazoline-2(1H)-thione 
• 79-11-8 chloroacetic acid 
• 100-52-7 benzaldehyde 
• 1078-19-9 6-methoxy-3,4-dihydro-1(2H)-naphthalenone 
• 3028-02-2 N-benzothiazol-2-yl-2-chloroacetamide 
• 587-65-5 N-chloroacetyl-aniline 

Downstream Products

• 1379610-90-8 (E)-3-methoxy-10-(4-methylbenzylidene)-7-phenyl-7,10-dihydro-5H-benzo[h]thiazolo[2,3-b]quinazoline-9(6H)-one 
• 1379610-91-9 (E)-3-methoxy-10-(4-methoxybenzylidene)-7-phenyl-7,10-dihydro-5H-benzo[h]-thiazoline-9(6H)-one 

Relevant academic research and scientific papers

Synthesis of fused thiazolo[3,2-a]pyrimidinones: N-aryl-2-chloroacetamides as doubly electrophilic building blocks

2-Chloro-N-phenylacetamide and N-(benzo[d]thiazol-2-yl)-2-chloroacetamide are doubly electrophilic building blocks for the formation of ring annulated thiazolo[3,2-a]pyrimidinone products. This synthetic route involves formation of the title compound in acceptable product yields by the elimination of the by-product, aniline/2-aminobenzothiazole. Analytical and spectral studies, as well as single crystal X-ray data on the representative compound 6c confirmed the structure of all the reaction products.

Ionic liquid-mediated facile synthesis and antimicrobial study of thiazolo [2,3-b]benzo[h]quinazolines and thiazino[2,3-b] benzo-[h]quinazolines

8-Methoxy-4-phenyl-3,4,5,6-tetrahydrobenzo[h]quinazoline-2(1H)-thione, obtained by the condensation of 2-benzylidene-6-methoxy-3,4-dihydronapthalene- 1(2H)-one with thiourea, on reaction with chloroacetic acid and 3-chloropropanoic acid in the presence of the ionic liquid N-methylpyridinium tosylate furnishes 3-methoxy-7-phenyl-7,10-dihydro-5H- benzo[h]thiazolo[2,3-b] quinazoline-9(6H)-one and 3-methoxy-7-phenyl-5,6,10,11-tetrahydro- benzo[h][1,3]thiazino[2,3-b]quinazoline-9(7H)-one. Further, condensation of the thione with 1,2-dibromoethane and 1,3-dibromopropane yields 3-methoxy-7-phenyl- 6,7,9,10-tetrahydro-5 H-benzo[h]thiazolo[2,3-b]quinazoline and 3-methoxy-7-phenyl-5,6,7,9,10,11-hexahydrobenzo [h][1,3]thiazino[2,3-b] quinazoline respectively. Arylidene derivatives have been obtained by two routes. The structures of the cyclized compounds have been established on the basis of elemental analysis and spectroscopic data. The synthesized compounds were screened for antimicrobial activity. Some of the compounds showed promising antimicrobial activities. Copyright