137968-28-6

Basic information

• Product Name: 1-(4-fluorobenzyl)-1H-pyrazol-5-amine
• Synonyms: 1-(4-fluorobenzyl)-1H-pyrazol-5-amine;1H-pyrazol-5-amine, 1-[(4-fluorophenyl)methyl]-;[2-(4-fluorobenzyl)pyrazol-3-yl]amine;2-[(4-fluorophenyl)methyl]-3-pyrazolamine;2-[(4-fluorophenyl)methyl]pyrazol-3-amine
• CAS NO: 137968-28-6
• Molecular Formula: C₁₀H₁₀FN₃
• Molecular Weight: 191.2049032
• Mol File: 137968-28-6.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-fluorobenzyl)-1H-pyrazol-5-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-fluorobenzyl)-1H-pyrazol-5-amine(137968-28-6)
• EPA Substance Registry System: 1-(4-fluorobenzyl)-1H-pyrazol-5-amine(137968-28-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 137968-28-6(Hazardous Substances Data)

Usage

General Description

1-(4-fluorobenzyl)-1H-pyrazol-5-amine is a chemical compound that belongs to the class of pyrazole derivatives. It is a small molecule with the chemical formula C10H10FN3. 1-(4-fluorobenzyl)-1H-pyrazol-5-amine is commonly used in pharmaceutical research and drug development due to its potential medicinal properties. It may have applications in the development of new drugs for various therapeutic indications such as anti-inflammatory, anti-cancer, or anti-microbial agents. Its structure contains a pyrazole ring with a fluoro-substituted benzyl group, which gives it unique pharmacological properties. Further research and studies are needed to fully understand its biological activities and potential uses in medicine.

Upstream product

• 1820-80-0 3-aminopyrazole 
• 137968-22-0 1-<(p-Fluorobenzyl)amino>pyrazole 

Relevant articles and documents

Design, synthesis and biological evaluation of spiropyrazolopyridone derivatives as potent dengue virus inhibitors

The effective treatment for dengue virus infection continues to be a challenge. We herein reported our continued SAR exploration on the spiropyrazolopyridone scaffold. Introducing different substituents at the 3?- or 5?-site of the pyrazolopyridone core or moving the benzyl chain to the adjacent nitrogen led to a significant loss of potency on DENV-2. While a narrow range of substitutions were tolerated at the para-position of the phenyl ring, di-substitution on the phenyl ring is beneficial for DENV-2 potency and has variable influences on DENV-3 potency depending on the exact compound. Among these molecules, compounds 22 (JMX0376) with 4-chloro-3-fluorobenzyl and 24 (JMX0395) with 2,4-bis(trifluoromethyl)benzyl showed the most potent and broadest inhibitory activities against DENV-1 to ?3 with nanomolar to low micromolar EC50 values.

TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS

The invention relates to tetrazole compounds of formula (I) wherein X, Y, Z, R1, R2 and R3 are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.