1379771-89-7Relevant academic research and scientific papers
Triple bioorthogonal ligation strategy for simultaneous labeling of multiple enzymatic activities
Willems, Lianne I.,Li, Nan,Florea, Bogdan I.,Ruben, Mark,Van Der Marel, Gijsbert A.,Overkleeft, Herman S.
, p. 4431 - 4434 (2012/06/18)
Three at the same time: A ligation strategy combining tetrazine-norbornene cycloaddition, Staudinger-Bertozzi ligation, and copper(I)-catalyzed click reaction was used to label the three catalytic activities of the proteasome simultaneously in a single experiment. The orthogonality of the three ligation reactions enables selective monitoring of multiple targets at the same time in complex biological samples. Copyright
