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Usage

Uses

Used in Pharmaceutical Industry:
1-(2,4-dihydroxyphenyl)-2-(2-fluorophenoxy)ethanone is used as a chemical intermediate for the production of various pharmaceuticals. Its unique structure and chemical properties contribute to the development of new drugs, with ongoing research into its biological and pharmacological activities.
Used in Agrochemical Industry:
In the agrochemical sector, 1-(2,4-dihydroxyphenyl)-2-(2-fluorophenoxy)ethanone serves as a crucial intermediate in the synthesis of agrochemicals. Its role in this industry is vital for the development of effective and environmentally friendly products.
Used in Dye Industry:
1-(2,4-dihydroxyphenyl)-2-(2-fluorophenoxy)ethanone is also utilized as an intermediate in the dye industry, where its distinctive chemical properties are harnessed to create a wide range of dyes with specific characteristics.
Used in Organic Synthesis and Drug Discovery Research:
Due to its unique structure and chemical properties, 1-(2,4-dihydroxyphenyl)-2-(2-fluorophenoxy)ethanone is a valuable building block in organic synthesis and drug discovery research. It aids in the development of novel compounds with potential applications in various industries, including pharmaceuticals, agrochemicals, and dyes.

Upstream product

• 367-12-4 2-fluorophenol 
• 137988-23-9 (2-Fluoro-phenoxy)-acetonitrile 

Downstream Products

• 137988-08-0 Acetic acid 3-(2-fluoro-phenoxy)-4-oxo-4H-chromen-7-yl ester 
• 137374-74-4 3-(2-Fluoro-phenoxy)-7-hydroxy-chromen-4-one 

Relevant academic research and scientific papers

ANTI-VIRULENCE COMPOSITIONS AND METHODS

A method of reducing the virulence of a bacterium that expresses accessory gene regulator A (AgrA) or an ortholog of AgrA includes administering to the bacterium an amount of a pharmaceutical composition effective to inhibit the synthesis of one or more virulence factors by the bacterium, the pharmaceutical composition including an AgrA antagonist.

Combinatorial synthesis and in vitro evaluation of a biaryl hydroxyketone library as antivirulence agents against mrsa

Antibiotic resistance coupled with decreased development of new antibiotics necessitates the search for novel antibacterial agents. Antivirulence agents offer an alternative to conventional antibiotics. In this work, we report on a family of small-molecule antivirulence agents against methicillin-resistant Staphylococcus aureus (MRSA), the most widespread bacterial pathogen. Structure-activity relationship studies led to the development of a concise synthesis of a 148-member biarylhydroxyketone library. An acylation bond-forming process afforded resorcinols (1) and aryloxy acetonitriles (2) as synthons. A Lewis-acid-activated Friedel-Crafts' acylation step involving a nitrile functionality of 2 by ZnCl2, followed by nucleophilic attack by 1 was executed to obtain biaryl hydroxyketones in excellent yields. A large number of products crystallized. This strategy affords a range of biarylhydroxyketones in a single step. This is the first collective synthetic study documenting access to this class of compounds through a single synthetic operation. In vitro efficacy of compounds in this library was evaluated by a rabbit erythrocyte hemolysis assay. The most efficacious compound, 4f-12, inhibits hemolysis by 98.1 ± 0.1% compared to control in the absence of the compound.