13799-33-2

Upstream product

• 13278-35-8 2-(4-chloroanilino)benzoic acid 
• 17264-73-2 sodium o-bromobenzoate 
• 106-47-8 4-chloro-aniline 
• 1679-18-1 4-Chlorophenylboronic acid 
• 28144-70-9 anthranilic acid amide 

Downstream Products

• 95216-40-3 1-(4-Chloro-phenyl)-2-cyclopropyl-1H-quinazolin-4-one 
• 70344-47-7 1-(4-Chloro-phenyl)-2-isopropyl-1H-quinazolin-4-one 
• 95216-42-5 1-(4-Chloro-phenyl)-2-cyclobutyl-1H-quinazolin-4-one 
• 13625-35-9 2-[(4-chlorophenyl)amino]benzonitrile 

Relevant academic research and scientific papers

Chemoselective: N -arylation of aminobenzamides via copper catalysed Chan-Evans-Lam reactions

Chemoselective N-arylation of unprotected aminobenzamides was achieved via Cu-catalysed Chan-Evans-Lam cross-coupling with aryl boronic acids for the first time. Simple copper catalysts enable the selective arylation of amino groups in ortho/meta/para-aminobenzamides under open-flask conditions. The reactions were scalable and compatible with a wide range of functional groups.

Preparation method for arylamine benzamides compounds and N-aryl-arylamine benzamides compounds

The invention provides a preparation method for arylamine benzamides compounds and N-aryl-arylamine benzamides compounds and belongs to the technical field of refining. According to the method provided by the invention, carbon nitrogen coupling reaction is performed by using arylboronic acid (or borate) as an aryl reagent under a copper-catalyzed condition, the reaction is performed at 10-35 DEG C and the selective arylation of aminophenamide is realized. Compared with the present Buchwald-Hartwig carbon nitrogen coupling reaction under palladium-catalyzed condition, the carbon nitrogen coupling reaction has the advantages that the catalyst is low in cost and low in toxicity, the raw materials are simple, easily acquired, stable and low-toxicity, the reaction temperature is greatly reduced, inert gas atmosphere protection is not required, the stirring reaction can be directly performed in an opening reaction flask under a room temperature condition, the condition is mild and the operation is easy, aniline locally has high-selective arylation reaction, the reaction yield is high, the product is easily purified and the atom economy is high.