137997-34-3

Upstream product

• 695-34-1 2-Amino-4-methylpyridine 
• 55919-47-6 ethyl 2-bromo-3-oxo-3-phenylpropionate 
• 342626-64-6 ethyl 3-(methoxyimino)-3-phenylpropanoate 
• 108-89-4 picoline 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 

Downstream Products

• 220465-49-6 7-methyl-2-phenylimidazo[1,2-a]pyridine-3-carboxylic acid 

Relevant academic research and scientific papers

Research on heterocyclic compounds, Part 40. 2-Phenylimidazo[1,2-a]pyridine-3-carboxylic acid derivatives: synthesis and antiinflammatory activity.

A series of 2-phenylimidazo[1,2-a]pyridine-3-carboxylic esters, acids, and amides were synthesized and pharmacologically tested in order to evaluate their antiinflammatory and analgesic activity and their ulcerogenic action on the gastro-intestinal tract. The most active member of this series of compounds was found to be 6-methyl-2-phenylimidazo[1,2-a]pyridine-3-carboxylic acid (5c).

Synthesis of imidazopyridines via copper-catalyzed, formal aza-[3 + 2] cycloaddition reaction of pyridine derivatives with α-diazo oxime ethers

The Cu-catalyzed, formal aza-[3 + 2] cycloaddition reaction of pyridine derivatives with α-diazo oxime ethers in trifluoroethanol was used to synthesize imidazopyridines via the release of molecular nitrogen and elimination of alcohol. These methods enabled modular synthesis of a wide range of N-heterobicyclic compounds such as imidazopyridazines, imidazopyrimidines, and imidazopyrazines with an α-imino Cu-carbenoid generated from the α-diazo oxime ethers and copper.

CBr4 Mediated Oxidative C-N Bond Formation: Applied in the Synthesis of Imidazo[1,2-α]pyridines and Imidazo[1,2-α]pyrimidines

The carbon tetrabromide mediated oxidative carbon-nitrogen bond formation of 2-aminopyridines or 2-aminopyrimidines with β-keto esters or 1,3-diones, leading to a variety of complex imidazo[1,2-α]pyridines or imidazo[1,2-α]pyrimidines, is reported. The re

Cu(I)-catalysed oxidative coupling of 2-aminopyridines with β-keto esters: Synthesis of imidazo[1,2-a]pyridine-3-carboxylates

A simple, economical, and environmentally friendly copper-catalysed direct oxidative C-N coupling of 2-aminopyridines with β-keto esters using air as oxidation agent for the creation of imidazo[1,2-a]pyridine-3-carboxylates is demonstrated. Imidazo[1,2-a]pyridine is the basic skeleton for a wide range of biological and pharmacological compounds.

Thermal and microwave-assisted rapid syntheses of substituted imidazo[1,2-a]pyridines under solvent- and catalyst-free conditions

Thermal and microwave-assisted rapid syntheses of highly substituted imidazo[1,2-a]pyridine derivatives by reaction of aminopyridines and -bromo - keto esters under solvent-free conditions are described. Reactions carried out under microwave irradiation give the highest yields of products in reaction times of less than two minutes. Georg Thieme Verlag Stuttgart New York.

TBAI-catalyzed oxidative coupling of aminopyridines with β-keto esters and 1,3-diones - Synthesis of imidazo[1,2-a]pyridines

TBAI could catalyze the direct oxidative C-N coupling of 2-aminopyridines with β-keto esters and 1,3-diones, which affords imidazo[1,2-a]pyridines as the products. The reaction was realized under metal-free conditions by using tert-butyl hydroperoxide (TB

Synthesis of imidazo[1,2-a]pyridines by the bis(acetyloxy)(phenyl)- λ3-iodane-Mediated oxidative coupling of 2-aminopyridines with β-keto esters and 1,3-diones

Imidazo[1,2-a]pyridine-3-carboxylates can be prepared directly from 2-aminopyridines and β-keto esters by using bis(acetyloxy)(phenyl)- λ3-iodane as an oxidant and boron trifluoride etherate as a catalyst. The amount of catalyst plays a key rol

Imidazopyridine derivatives as angiotensin II receptor antagonists, pharmaceuticals, and treatment of hypertension therewith

Imidazo-fused iso- and heterocycles, process for their preparation, compositions containing them and their useA compound of the formula STR1 in which the symbols have the following meaning: X is a monocyclic radical having 3,4 or 5 ring atoms,R 1,R 2,R 3,