2-(aMinoMethyl)-1,5-bis(benzyloxy)pyridin-4(1H)-one Methanesulfonate

Base Information

• Chemical Name: 2-(aMinoMethyl)-1,5-bis(benzyloxy)pyridin-4(1H)-one Methanesulfonate
• CAS No.: 1380112-29-7
• Molecular Formula: C21H24N2O6S
• Molecular Weight: 432.497
• Mol file: 1380112-29-7.mol

Synonyms:2-(aMinoMethyl)-1,5-bis(benzyloxy)pyridin-4(1H)-one Methanesulfonate

Chemical Property of 2-(aMinoMethyl)-1,5-bis(benzyloxy)pyridin-4(1H)-one Methanesulfonate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(aMinoMethyl)-1,5-bis(benzyloxy)pyridin-4(1H)-one Methanesulfonate

There total 8 articles about 2-(aMinoMethyl)-1,5-bis(benzyloxy)pyridin-4(1H)-one Methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

methanesulfonic acid (75-75-2,98527-29-8) + 2-(aminomethyl)-1,5-bis(benzyloxy)-1,4-dihydropyridin-4-one (1380109-80-7) → CH4O3S*C20H20N2O3 (1380112-29-7)

Guidance literature:

In water; ethyl acetate; at 20 - 50 ℃;

Reference yield:

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one (501-30-4,123712-78-7) → CH4O3S*C20H20N2O3 (1380112-29-7)

Guidance literature:

Multi-step reaction with 7 steps

1: sodium hydroxide / methanol; water / 0.17 h / Reflux

2: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 60 °C

3: potassium carbonate / dimethyl sulfoxide / 1 h / 20 °C

4: triethylamine / dichloromethane / 1 h / 0 °C

5: potassium iodide / N,N-dimethyl-formamide / 20 °C

6: hydrazine hydrate / ethanol / 1 h / Reflux

7: ethyl acetate / 2 h / 50 °C

With hydroxylamine hydrochloride; sodium acetate; potassium carbonate; hydrazine hydrate; triethylamine; potassium iodide; sodium hydroxide; In methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm400560z

Reference yield:

benzyl bromide (100-39-0) → CH4O3S*C20H20N2O3 (1380112-29-7)

Guidance literature:

Multi-step reaction with 7 steps

1: sodium hydroxide / methanol; water / 0.17 h / Reflux

2: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 60 °C

3: potassium carbonate / dimethyl sulfoxide / 1 h / 20 °C

4: triethylamine / dichloromethane / 1 h / 0 °C

5: potassium iodide / N,N-dimethyl-formamide / 20 °C

6: hydrazine hydrate / ethanol / 1 h / Reflux

7: ethyl acetate / 2 h / 50 °C

With hydroxylamine hydrochloride; sodium acetate; potassium carbonate; hydrazine hydrate; triethylamine; potassium iodide; sodium hydroxide; In methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm400560z

upstream raw materials:

benzyl bromide

methanesulfonic acid

2-(aminomethyl)-1,5-bis(benzyloxy)-1,4-dihydropyridin-4-one

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

Downstream raw materials:

C₂₆H₂₂FN₃O₄

C₂₉H₂₆N₂O₆

C₂₇H₂₄N₂O₇S

tert-butyl ((2R,3S)-2-((3-((1,5-bis-(benzyloxy)-4-oxo-1,4-dihydropyridin-2-yl)methyl)ureido)-methyl)-1-(2,4-dimethoxybenzyl)-4-oxoazetidin-3-yl)-carbamate