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Usage

Uses

Used in Pharmaceutical Industry:
N,N-dimethyl(piperidin-4-yl)methanamine hydrochloride is used as an intermediate in the synthesis of drugs for neurological and psychiatric disorders. Its ability to act as a ligand for various receptors and enzymes makes it a valuable component in the development of medications targeting these conditions.

Upstream product

• 254905-58-3 4-(dimethylcarbamoyl)piperidine-1-carboxylic acid tert-butyl ester 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 138022-01-2 4-((dimethylamino)methyl)piperidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 864247-90-5 4-(4-Amino-2-fluorophenoxy)-2-{[4-(dimethylaminomethyl)piperidin-1-yl]carbonylamino}pyridine 

Relevant academic research and scientific papers

Compounds with growth hormone releasing properties

Disclosed are compounds of formula I formula I wherein R1, R2, R5, R6, R7, R8, G, J, L, M, a, b, c, d, e, and f are as defined in the specification, and compositions containing them. These

The influence of conformational restriction in the C-terminus of growth hormone secretagogues on their potency

In order to obtain more potent growth hormone secretagogues, a comparison of ipamorelin and NN703 suggested the addition of a polar group at the C-terminus of NN703. A study was conducted using constrained amines for this purpose. Here, substituted 4-piperidinylamino- and 4-dimethylaminopiperidino-substitutents were found to give the most active compounds. A replacement of the 4-dimethylaminopiperidino-substituent with 4-hydroxypiperidino resulted in a series of compounds, which showed in vitro activity with EC50 values in the low nanomolar range, and favourable kinetic properties, such as 40% oral bioavailability. The most promising compound was also tested in a swine in vivo model, resulting in a growth hormone level with a Cmax of over 40 ng mL-1.