1380278-35-2Relevant academic research and scientific papers
Quaternary Centers by Nickel-Catalyzed Cross-Coupling of Tertiary Carboxylic Acids and (Hetero)Aryl Zinc Reagents
Chen, Tie-Gen,Zhang, Haolin,Mykhailiuk, Pavel K.,Merchant, Rohan R.,Smith, Courtney A.,Qin, Tian,Baran, Phil S.
, p. 2454 - 2458 (2019)
This work bridges a gap in the cross-coupling of aliphatic redox-active esters with aryl zinc reagents. Previously limited to primary, secondary, and specialized tertiary centers, a new protocol has been devised to enable the coupling of general tertiary systems using nickel catalysis. The scope of this operationally simple method is broad, and it can be used to simplify the synthesis of medicinally relevant motifs bearing quaternary centers.
Simplifying iron-phosphine catalysts for cross-coupling reactions
Bedford, Robin B.,Carter, Emma,Cogswell, Paul M.,Gower, Nicholas J.,Haddow, Mairi F.,Harvey, Jeremy N.,Murphy, Damien M.,Neeve, Emily C.,Nunn, Joshua
supporting information, p. 1285 - 1288 (2013/03/13)
Any old iron? Iron catalysts based on the widely available diphosphine ligand bis(diphenylphosphino)ethane have not previously fared particularly well in iron-catalyzed cross-coupling processes. However, this turns out not to be due to any inherently poor performance associated with the ligand, but rather the need to form a bis-chelate complex, either before or during the formation of an active FeI species. Copyright
