1380288-25-4Relevant academic research and scientific papers
Rapid Assembly of Diversely Functionalized Spiroindenes by a Three-Component Palladium-Catalyzed C?H Amination/Phenol Dearomatization Domino Reaction
Fan, Liangxin,Liu, Jingjing,Bai, Lu,Wang, Yaoyu,Luan, Xinjun
supporting information, p. 14257 - 14261 (2017/10/31)
A novel palladium-catalyzed three-component reaction of phenol-derived biaryls with N-benzoyloxyamines and norbornadiene (NBD) has been developed for the assembly of highly functionalized spiroindenes. This domino process was realized through NBD-assisted C?H amination and phenol dearomatization by forming one C?N bond and two C?C bonds in a single step. Preliminary studies indicated that asymmetric control of this transformation was feasible with chiral ligands. Moreover, the potential synthetic utility of this methodology was highlighted by a series of further transformations.
Synthesis of hindered anilines: Copper-catalyzed electrophilic amination of aryl boronic esters
Rucker, Richard P.,Whittaker, Aaron M.,Dang, Hester,Lalic, Gojko
supporting information; experimental part, p. 3953 - 3956 (2012/06/04)
No longer a hindrance: Copper-catalyzed electrophilic amination of aryl boronic esters is accomplished under mild reaction conditions using 2.5-5.0 mol % of a catalyst derived from copper tert-butoxide and Xantphos ligand (see scheme). The reaction tolerates a wide range of functional groups and can be used to prepare some of the most hindered anilines made to date. Copyright
