1380395-58-3

Basic information

• Product Name: 2-(5-(2-aminopyridin-4-yl)-1,3,4-oxadiazol-2-ylthio)-1-phenylethanone
• CAS NO: 1380395-58-3
• Molecular Weight: 312.352
• Mol File: 1380395-58-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(5-(2-aminopyridin-4-yl)-1,3,4-oxadiazol-2-ylthio)-1-phenylethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-(2-aminopyridin-4-yl)-1,3,4-oxadiazol-2-ylthio)-1-phenylethanone(1380395-58-3)
• EPA Substance Registry System: 2-(5-(2-aminopyridin-4-yl)-1,3,4-oxadiazol-2-ylthio)-1-phenylethanone(1380395-58-3)

Safety Data

• Hazardous Substances Data: 1380395-58-3(Hazardous Substances Data)

Upstream product

• 58481-01-9 2-aminoisonicotinic acid hydrazide 
• 6937-03-7 methyl 2-aminoisonicotinate 

Relevant articles and documents

Synthesis, biological evaluation and molecular docking studies of novel 2-(1,3,4-oxadiazol-2-ylthio)-1-phenylethanone derivatives

In present study, a series of new 2-(1,3,4-oxadiazol-2-ylthio)-1- phenylethanone derivatives (6a-6x) as potential focal adhesion kinase (FAK) inhibitors were synthesized. The bioassay assays demonstrated that compound 6i showed the most potent activity, which inhibited the growth of MCF-7 and A431 cell lines with IC50 values of 140 ± 10 nM and 10 ± 1 nM, respectively. Compound 6i also exhibited significant FAK inhibitory activity (IC50 = 20 ± 1 nM). Docking simulation was performed to position compound 6i into the active site of FAK to determine the probable binding model.