58481-01-9

Basic information

• Product Name: 2-AMINO-ISONICOTINIC ACID HYDRAZIDE
• Synonyms: 2-AMINO-ISONICOTINIC ACID HYDRAZIDE;2-Amino-isonicotinic acid hydrazide ,97%;2-Aminoisonicotinohydrazide;4-pyridinecarboxylic acid, 2-amino-, hydrazide;2-Amino-isonicotinic acid hydrazide AldrichCPR;2-amino-4-pyridinecarbohydrazide;2-aminopyridine-4-carbohydrazide;AIDS070057
• CAS NO: 58481-01-9
• Molecular Formula: C₆H₈N₄O
• Molecular Weight: 152.15
• Mol File: 58481-01-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 190.9-191.3°C
• Appearance: /
• Density: 1.352 g/cm³
• Refractive Index: 1.651
• PKA: 11.23±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-ISONICOTINIC ACID HYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-ISONICOTINIC ACID HYDRAZIDE(58481-01-9)
• EPA Substance Registry System: 2-AMINO-ISONICOTINIC ACID HYDRAZIDE(58481-01-9)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 58481-01-9(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow solid

InChI:InChI=1/C6H8N4O/c7-5-3-4(1-2-9-5)6(11)10-8/h1-3H,8H2,(H2,7,9)(H,10,11)

Upstream product

• 13362-30-6 2-amino-4-ethoxycarbonyl-pyridine 
• 13362-28-2 2-aminoisonicotinic acid 
• 6937-03-7 methyl 2-aminoisonicotinate 

Downstream Products

• 917462-03-4 2-aminoisonicotinic acid (4-fluorobenzylidine) hydrazide 
• 1357083-14-7 4-(5-(benzylthio)-1,3,4-oxadiazol-2-yl)pyridin-2-amine 
• 1380395-63-0 2-(5-(2-aminopyridin-4-yl)-1,3,4-oxadiazol-2-ylthio)-1-(4-bromophenyl)ethanone 
• 1380395-58-3 2-(5-(2-aminopyridin-4-yl)-1,3,4-oxadiazol-2-ylthio)-1-phenylethanone 
• 917462-07-8 2-[N¹-(4-acetylsulfanilamido)]-4-[5-(methylthio)-[1,3,4]-oxadiazol-2-yl]pyridine 

Relevant articles and documents

2-pyridine substituted urea structural small molecule compounds as well as synthesis and application thereof

The invention relates to 2-pyridine substituted urea structural small molecule compounds as well as synthesis and application thereof. Specifically, the invention discloses the compounds represented by a formula (I) shown in the specification, enantiomers, diastereomers, racemates or a mixture of the compounds, or a pharmaceutically acceptable salt, hydrate and solvate of the compounds, a preparation method of the above materials, and applications of the above materials in preparation of an ASK1 small molecule inhibitor, or medicines for preventing and/or treating diseases related to ASK1, especially liver diseases, lung diseases, cardiovascular diseases, kidney diseases and metabolic diseases.

Synthesis, biological evaluation and molecular docking studies of novel 2-(1,3,4-oxadiazol-2-ylthio)-1-phenylethanone derivatives

In present study, a series of new 2-(1,3,4-oxadiazol-2-ylthio)-1- phenylethanone derivatives (6a-6x) as potential focal adhesion kinase (FAK) inhibitors were synthesized. The bioassay assays demonstrated that compound 6i showed the most potent activity, which inhibited the growth of MCF-7 and A431 cell lines with IC50 values of 140 ± 10 nM and 10 ± 1 nM, respectively. Compound 6i also exhibited significant FAK inhibitory activity (IC50 = 20 ± 1 nM). Docking simulation was performed to position compound 6i into the active site of FAK to determine the probable binding model.

Synthesis and preliminary anti-bacterial activity of some 4-substituted-N1-2-pyridylsulfanilamide derivatives

2-Amino-4-ethoxycarbonylpyridine 1 was used as a starting material in the synthesis of some 4-substituted-N′-2-pyridylsulfanilamide derivatives to evaluate their antimicrobial activity. The obtained compounds were of no particular effect against the teste