1380402-49-2

Upstream product

• 201230-82-2 carbon monoxide 
• 100-39-0 benzyl bromide 
• 63591-85-5 phenylacetic acid N-hydroxysuccinimide ester 
• 358621-92-8 N-(p-tolylsulfonyl)-1,3-diphenyl-2-propen-1-imine 
• 103-82-2 phenylacetic acid 
• 103-80-0 phenylacetyl chloride 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 143121-73-7 (E)-1,3-diphenyl-1-<<('4-methylphenyl)sulfonyl>imino>-2-propene 
• 864658-42-4 2,2-dimethylpropanoicphenylacetic anhydride 
• 70-55-3 toluene-4-sulfonamide 

Downstream Products

• 1380402-74-3 (3R,4R)-3,4,6-triphenyl-5-tosyl-3,4-dihydropyridin-2(1H)-one 
• 1380402-76-5 (3R,4R)-3,4,6-triphenyl-3,4-dihydropyridin-2(1H)-one 
• 1380402-75-4 (3R,4R)-3,4,6-triphenyl-5-tosyl-1,2,3,4-tetrahydropyridine 
• 1380402-77-6 (3R,4R)-3,4,6-triphenyl-2,3,4,5-tetrahydropyridine 
• 1380402-79-8 N-((3R,4R,E)-5-hydroxy-1,3,4-triphenylpent-1-en-1-yl)-4-methylbenzenesulfonamide 
• 1380402-78-7 (2R,4R,5R)-2,4,5-triphenylpiperidine 
• 1380402-81-2 (2R,4R,5R)-2,4,5-triphenyl-1-tosylpiperidine 

Relevant academic research and scientific papers

Catalytic Generation of C1 Ammonium Enolates from Halides and CO for Asymmetric Cascade Reactions

A general strategy for the design of asymmetric cascade reactions using readily available halides and carbon monoxide (CO) as substrates is developed. The key is the catalytic generation of C1-ammonium enolates for the subsequent asymmetric cascade reactions through the combination of palladium-catalyzed carbonylation and chiral Lewis base catalysis. Utilizing this strategy, we have established asymmetric formal [1+1+4] and [1+1+2] reactions to afford chiral dihydropyridones and β-lactams with high yields and high enantio- and diastereoselectivities.

An Upstream By-product from Ester Activation via NHC-Catalysis Catalyzes Downstream Sulfonyl Migration Reaction

A sequential reaction combining N-heterocyclic carbene (NHC) and N-hydroxyphthalimide (NHPI) catalysis allowed for the upstream by-product NHPI, which was generated in the NHC-catalyzed cycloaddition reaction, to act as the catalyst for a downstream nitro

A Recyclable, Immobilized Analogue of Benzotetramisole for Catalytic Enantioselective Domino Michael Addition/Cyclization Reactions in Batch and Flow

A polystyrene-supported, enantiopure benzotetramisole (BTM) analogue (5) has been synthesized from (2S,3S)-phenylglycidol through a five-step sequence involving a copper-catalyzed alkyne azide cycloaddition (CuAAC) reaction as the final, immobilization st

Enantioselective activation of stable carboxylate esters as enolate equivalents via N-heterocyclic carbene catalysts

The first N-Heterocyclic Carbene (NHC) mediated activation of stable carboxylate esters to generate enolate intermediates is disclosed. The catalytically generated arylacetic ester enolates undergo enantioselective reactions with α,β-unsaturated imines.

Dihydropyridones: Catalytic asymmetric synthesis, N- to C-sulfonyl transfer, and derivatizations

Benzotetramisole (1) promotes the reaction of ammonium enolates derived from arylacetic acids with N-tosyl-α,β-unsaturated ketimines, thus giving dihydropyridones with high diastereo- and enantiocontrol (see scheme). These products readily undergo N- to C-sulfonyl photoisomerization and are derivatized to afford stereodefined piperidines and tetrahydropyrans.