1380424-11-2Relevant academic research and scientific papers
Buchwald-Hartwig coupling/Michael addition reactions: One-pot synthesis of 1,2-disubstituted 4-quinolones from chalcones and primary amines
Fei, Xiang-Dong,Zhou, Zhou,Li, Wen,Zhu, Yong-Ming,Shen, Jing-Kang
, p. 3001 - 3008 (2012/07/13)
The Buchwald-Hartwig coupling/Michael addition sequence has been successfully applied to the synthesis of functionalized 1,2-disubstituted 4-quinolones using Pd(OAc)2 as a catalyst and PPh3 as a ligand. Under these conditions, the intermediate products first formed from chalcones and primary amines underwent catalytic dehydrogenation to yield the 1,2-disubstituted 4-quinolones. Copyright
