1380429-32-2

Upstream product

• 6294-93-5 4-chloro-3-trifluoromethylphenol 
• 516481-95-1 4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}benzaldehyde 
• 74-89-5 methylamine 
• 459-57-4 4-fluorobenzaldehyde 

Relevant academic research and scientific papers

PYRIMIDONE COMPOUNDS USED AS LP-PLA2 INHIBITORS AND PHARMACEUTICAL COMPOSITIONS THEREOF

The present invention relates to pyrimidone compounds used as Lp-PLA2 inhibitors and pharmaceutical compositions thereof. The structure of the pyrimidone compounds is represented by general formula (I), wherein R1, R2, Rs

PYRIMIDINONE COMPOUNDS FOR USE IN THE TREATMENT OF DISEASES OR CONDITIONS MEDIATED BY LP - PLA2

The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease, and/or diabetic macular edema (I).