1380434-41-2Relevant academic research and scientific papers
Gram-scale ketone synthesis by direct reductive coupling of alkyl iodides with acid chlorides
Lu, Wenbin,Liang, Zhuye,Zhang, Yuwei,Wu, Fan,Qian, Qun,Gong, Hegui
, p. 2234 - 2240 (2013/09/02)
Alkyl aryl ketones were prepared on a gram scale by the nickel-catalyzed reductive coupling of alkyl iodides with aroyl chlorides. When scaled up 30-fold, this reaction shows a comparable coupling efficiency to the previously reported reaction performed under small-scale conditions. The mild and convenient reaction conditions show excellent tolerance to a range of functional groups and provide the ketones in good to excellent yields. Georg Thieme Verlag Stuttgart. New York.
Ketone formation via mild Nickel-catalyzed reductive coupling of alkyl halides with aryl acid chlorides
Wu, Fan,Lu, Wenbin,Qian, Qun,Ren, Qinghua,Gong, Hegui
supporting information; experimental part, p. 3044 - 3047 (2012/08/07)
The present work highlights unprecedented Ni-catalyzed reductive coupling of unactivated alkyl iodides with aryl acid chlorides to efficiently generate alkyl aryl ketones under mild conditions.
