1380449-95-5

Upstream product

• 130723-13-6 3-bromo-5-fluorobenzotrifluoride 
• 939039-29-9 (5-chloropyridin-2-yl)(3-fluoro-5-(trifluoromethyl)phenyl)methanone 
• 89809-64-3 2-cyano-5-chloropyridine 
• 300-87-8 3,5-dimethyl-1,2-oxazole 
• 939039-30-2 C₁₇H₁₅ClF₄N₂OS 

Relevant academic research and scientific papers

Synthesis of tertiary carbinamines

An efficient synthesis of tertiary carbinamines using a one-pot, three-component reaction employing TMSCl activation of an intermediate imine salt followed by addition of an organometallic is described. An optimized second generation chiral synthesis of select tertiary carbinamines utilizing the Ellman sulfinamine was subsequently developed on a multi-gram scale and is also described.