1380503-00-3Relevant academic research and scientific papers
Ruthenium(II)-catalyzed direct addition of indole/pyrrole C2-H bonds to alkynes
Liang, Libo,Fu, Shaomin,Lin, Dongen,Zhang, Xiao-Qi,Deng, Yuanfu,Jiang, Huanfeng,Zeng, Wei
, p. 9472 - 9480 (2014)
A ruthenium-catalyzed C2-hydroindolation of alkynes has been achieved. This protocol provides a rapid and concise access to kinds of 2-alkenyl-substituted N-(2-pyridyl)-indoles in which the pyridyl moiety can be easily removed to afford free (N-H) indoles under mild conditions. Various arenes and alkynes, including electron-deficient and electron-rich internal alkynes and terminal alkynes, allow for this transformation. (Chemical Equation Presented).
Isolation of Cp*CoIII–Alkenyl Intermediate in Efficient Cobalt-Catalyzed C?H Alkenylation with Alkynes
Sen, Malay,Rajesh, Nimmakuri,Emayavaramban, Balakumar,Premkumar, J. Richard,Sundararaju, Basker
supporting information, p. 342 - 346 (2018/01/17)
A general and efficient procedure for C?H alkenylation of arenes with a broad substrate scope catalyzed by Cp*CoIII was demonstrated with alkynes. A highly selective mono-alkenylation and sequential bis-C?H bond functionalization was displayed to exemplify the versatility of the cobalt catalyst. Isolation of cationic Cp*CoIII–alkenyl intermediate was achieved under identical catalytic conditions to further establish the proposed pathway.
Manganese catalyzed C-H functionalization of indoles with alkynes to synthesize bis/trisubstituted indolylalkenes and carbazoles: The acid is the key to control selectivity
Shi, Lijun,Zhong, Xiang,She, Houde,Lei, Ziqiang,Li, Fuwei
supporting information, p. 7136 - 7139 (2015/04/27)
The Mn-catalyzed C-H alkenylation reactions of indole with terminal- and internal-alkynes have been developed. In the presence of a catalytic amount of acid, the procedure efficiently affords bis/trisubstituted indolyl-alkenes in a highly regio- and stereo-selective manner. Without the addition of acid, the reaction undergoes a [2+2+2] cyclization process to give carbazoles with release of hydrogen gas. Notably, the directing pyrimidyl group can be readily removed. Experimental studies reveal that the reaction is initiated by a C-H activation step and the acid is the selectivity controller via a hydrogen transfer process. This journal is
Mild and efficient C2-alkenylation of indoles with alkynes catalyzed by a cobalt complex
Ding, Zhenhua,Yoshikai, Naohiko
scheme or table, p. 4698 - 4701 (2012/07/03)
Direct alkenylation of the C2-position of indoles bearing an easily removable N-pyrimidyl group with alkynes has been achieved by using a cobalt catalyst complexed with a phosphine-pyridine bidentate ligand. This reaction has wide substrate scope and is highly efficient and stereoselective at room temperature. The alkenylated indoles serve as useful platforms for further synthetic transformations (some products of these transformations are shown in the scheme). Copyright
