1380595-49-2

Upstream product

• 110-89-4 piperidine 
• 1380595-48-1 C₁₇H₂₀INO₄ 
• 98-80-6 phenylboronic acid 
• 58123-77-6 3-hydroxy-4-iodobenzoic acid 

Downstream Products

• 1380595-47-0 3-benzyl-6-(piperidine-1-carbonyl)-2,3-dihydro-benzofuran-3-carboxylic acid 
• 1196995-96-6 ((R)-(3-benzyl-3-methyl-2,3-dihydro-benzofuran-6-yl)-piperidin-1-yl-methanone) 

Relevant academic research and scientific papers

A synthetic approach for (S)-(3-benzyl-3-methyl-2,3-dihydro-benzofuran-6- yl)-piperidin-1-yl-methanone, a selective CB2 receptor agonist

(S)-(3-Benzyl-3-methyl-2,3-dihydro-benzofuran-6-yl)-piperidin-1-yl- methanone, a selective CB2 receptor agonist, was obtained from 3-hydroxy-4-iodo benzoic acid in nine steps with 97.4% ee and 3.4% total yield, which involved palladium catalyzed tandem intramolecular Heck/Suzuki cross coupling reaction, chemical resolution with (+)-norephedrine and Wolf-Kishner reaction as the key steps. (S)-(3-Benzyl-3-methyl-2,3-dihydro-benzofuran-6-yl)-piperidin-1-yl- methanone will be evaluated in vivo studies and this approach will be applied in the optimization process of CB2 receptor agonist.