138060-07-8

Basic information

• Product Name: 3-Aminopiperidine dihydrochloride
• Synonyms: 3-AMINOPIPERIDINE DIHYDROCHLORIDE;3-AMINOPIPERIDINE 2HCL;3-aminopiperidine hydrochloride;3-Aminopiperidine dihydrochloride 97%;3-AMINOPIPERIDINEDIHCL;3-AMINOPIPERIDINEHCL;3-AMINOPIPERIDINE PIPERIDIN-3-YLAMINE;piperidin-3-amine
• CAS NO: 138060-07-8
• Molecular Formula: C₅H₁₂N₂*2ClH
• Molecular Weight: 173.08
• EINECS: 1592732-453-0
• Product Categories: FINE Chemical & INTERMEDIATES;pharmacetical;Amines;Pyrans, Piperidines &Piperazines;Piperidine;Piperidines;Pyrans, Piperidines & Piperazines;Building Blocks;Heterocyclic Building Blocks
• Mol File: 138060-07-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 230 °C (dec.)(lit.)
• Boiling Point: 241.9°C at 760 mmHg
• Flash Point: 100.1°C
• Appearance: Off-white to beige/Powder
• Vapor Pressure: 0.028mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Methanol (Sparingly), Water (Slightly)
• Water Solubility: Partly miscible in water.
• Sensitive: Hygroscopic
• CAS DataBase Reference: 3-Aminopiperidine dihydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Aminopiperidine dihydrochloride(138060-07-8)
• EPA Substance Registry System: 3-Aminopiperidine dihydrochloride(138060-07-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-36
• WGK Germany: 3
• Hazardous Substances Data: 138060-07-8(Hazardous Substances Data)

Usage

Chemical Properties

Off-white to beige powder

Uses

Different sources of media describe the Uses of 138060-07-8 differently. You can refer to the following data:
1. Reactant for N-arylation of heterocyclic diamines Reactant for synthesis of substituted quinolones with reduced phototoxic risk
2. It is used as a reactant for N-arylation of heterocyclic diamines and for synthesis of substituted quinolones with reduced phototoxic risk.
3. Reactant for N-arylation of heterocyclic diaminesReactant for synthesis of substituted quinolones with reduced phototoxic risk

General Description

Estimation of (S)-piperidin-3-amine in (R)-piperidin-3-amine dihydrochloride (3-aminopiperidine dihydrochloride) has been investigated by chiral high-performance liquid chromatographic (chiral HPLC) method.

InChI:InChI=1/C5H12N2.2ClH/c6-5-2-1-3-7-4-5;;/h5,7H,1-4,6H2;2*1H/t5-;;/m1../s1

Upstream product

• 184637-48-7 t-butyl piperidin-3-ylcarbamate 
• 397246-12-7 (1,5-dihydroxypent-2-yl)carbamic acid tert-butyl ester 
• 861658-15-3 1,5-dimethyl 2-[(t-butoxycarbonyl)amino]pentanedioate 
• 617-65-2 Glutamic acid 
• 6525-53-7 glutamic acid dimethyl ether 
• 1622856-04-5 piperidine-3-carboxylic acid hydrazide monohydrochloride 
• 689758-90-5 piperidine-3-carboxylic acid hydrazide 
• 71962-74-8 Ethyl nipecotate 
• 4138-26-5 nipecotamide 
• 1353094-64-0 N-acetyl-3-aminopiperidine acetate 
• 1352756-67-2 N-acetyl-3-aminopyridine acetate 
• 462-08-8 pyridin-3-ylamine 

Downstream Products

• 485820-41-5 8-(3-aminopiperidin-1-yl)-7-(2-bromobenzyl)-1,3-dimethyl-3,7-dihydropurine-2,6-dione trifluoroacetate 
• 485820-18-6 2-(8-(3-aminopiperidin-1-yl)-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropurin-7-ylmethyl)benzonitrile trifluoroacetate 
• 1352756-66-1 (R)-piperidine-3-amine dibenzoyl-D-tartrate 
• 334618-23-4 3-(R)-aminopiperidine dihydrochloride 
• 190654-14-9 6-(3-chloro-phenyl-amino)-9-ethyl-2-(3-formylamino-piperidin-1-yl)-9H-purine 
• 668271-78-1 1,3-dimethyl-7-(2,6-dicyano-benzyl)-8-(3-amino-piperidin-1-yl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purine 
• 842135-73-3 isoquinoline-5-sulphonic acid piperidin-3-ylamide 
• 940907-93-7 2-((2-(3-aminopiperidin-1-yl)-4-oxoquinazolin-3(4H)-yl)methyl)benzonitrile 
• 956468-14-7 N-(1-{[3,4-bis(methyloxy)phenyl]sulfonyl}-3-piperidinyl)-3,4-bis(methyloxy)benzenesulfonamide 

Relevant articles and documents

Synthetic process of anti-hyperglycemic drug intermediate R-3-amino-piperidine dihydrochloride

The invention relates to a synthetic process of an anti-hyperglycemic drug intermediate R-3-amino-piperidine dihydrochloride. The synthetic process comprises the steps: using inexpensive L-glutamic acid as a starting material, and performing esterification, amino protection, reduction, hydroxyl protection, substitution, cyclization and removal of protecting groups for amino groups so as to obtainthe R-3-amino-piperidine dihydrochloride. Compared with the prior art, the synthetic process has cheap and easily available raw materials, good selectivity, good atomic economy, high total yield and mild reaction conditions, and is suitable for industrial production.

PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED 3-AMINOPIPERIDINE

The present invention relates to a process for the preparation of enantiomerically enriched 3-aminopiperidine, and in particular of its R-enantiomer (R)-3-aminopiperidine. The invention also relates to an enantiomerically enriched intermediate of said process and to specific acid-addition salts of 3-aminopiperidine (hereinafter also APIP) that are useful for obtaining a single enantiomer of APIP, and to crystalline (R)-3-aminopiperidine-dihydrochloride-monohydrateand crystalline (S)-3-aminopiperidine-dihydrochloride-monohydrate.

PROCESS FOR THE PREPARATION OF A SINGLE ENANTIOMER OF 3-AMINOPIPERIDINE DIHYDROCHLORIDE

A process comprising: (a) reduction of N-acetyl-3-aminopyridine (2): or its salt in the presence of hydrogen and a palladium catalyst deposited on solid support; (b) converting racemic N-acetyl-3-aminopiperidine (3) or its salt produced in step (a) to rac-3-aminopiperidine (rac-4) or its salt; (c) resolution of the racemic 3-aminopiperidine (rac-4) or its salt produced in step (b) with a chiral acid.