1380650-48-5Relevant academic research and scientific papers
A one-pot method synthesis of α-chloroketone dimethyl acetals
Zhou, Zhong-Shi,Li, Li,He, Xue-Han
, p. 633 - 635 (2013)
A new one-pot method has been developed for the direct preparation of α-chloroketone dimethyl acetals from ketones using ammonium chloride as the source of chlorine and potassium monoperoxysulfate as the oxidant in the presence of trimethyl orthoformate in methanol at room temperature. Ketones which have electron-withdrawing groups on the aryl rings gave the corresponding a-chloroketone dimethyl acetals in moderate to good yields.
Mild and efficient α-chlorination of carbonyl compounds using ammonium chloride and oxone (2KHSO5·KHSO4· K2SO4)
Swamy, Peraka,Kumar, MacHarla Arun,Reddy, Marri Mahender,Narender, Nama
supporting information; experimental part, p. 432 - 434 (2012/06/01)
A simple protocol for the α-monochlorination of ketones and 1,3-dicarbonyl compounds utilizing NH4Cl as a source of chlorine and Oxone as an oxidant in methanol without catalyst is presented. The reaction proceeds at ambient temperature in yields ranging from moderate to excellent.
