1380672-92-3

Basic information

• Product Name: 4-chloro-N'-[(E)-3-[4-(2-chlorophenyl)-5-(5-methylsulfonyl-2-pyridyl)-1,2,4-triazol-3-yl]prop-2-enoyl]benzohydrazide
• Synonyms: 4-chloro-N'-[(E)-3-[4-(2-chlorophenyl)-5-(5-methylsulfonyl-2-pyridyl)-1,2,4-triazol-3-yl]prop-2-enoyl]benzohydrazide
• CAS NO: 1380672-92-3
• Molecular Weight: 557.417
• Mol File: 1380672-92-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-chloro-N'-[(E)-3-[4-(2-chlorophenyl)-5-(5-methylsulfonyl-2-pyridyl)-1,2,4-triazol-3-yl]prop-2-enoyl]benzohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-N'-[(E)-3-[4-(2-chlorophenyl)-5-(5-methylsulfonyl-2-pyridyl)-1,2,4-triazol-3-yl]prop-2-enoyl]benzohydrazide(1380672-92-3)
• EPA Substance Registry System: 4-chloro-N'-[(E)-3-[4-(2-chlorophenyl)-5-(5-methylsulfonyl-2-pyridyl)-1,2,4-triazol-3-yl]prop-2-enoyl]benzohydrazide(1380672-92-3)

Safety Data

• Hazardous Substances Data: 1380672-92-3(Hazardous Substances Data)

Upstream product

• 1380672-89-8 N-(2-chlorophenyl)-5-(methylsulfonyl)picolinimidoyl chloride 
• 1380672-72-9 N′-(2-chlorophenyl)-5-(methylsulfonyl)picolinimidohydrazide 
• 1380672-71-8 N-(2-chlorophenyl)-5-(methylsulfonyl)picolinamide 
• 1201326-81-9 methyl 5-methanesulfonylpyridine-2-carboxylate 
• 1129-35-7 4-cyanobenzoic acid methyl ester 
• 29682-15-3 methyl 5-bromopicolinate 
• 30766-11-1 5-bromoisonicotinic acid 

Downstream Products

• 1380672-08-1 2-(4-(2-chlorophenyl)-5-((E)-2-(5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl)vinyl)-4H-1,2,4-triazol-3-yl)-5-(methylsulfonyl)pyridine 

Relevant articles and documents

TRIAZOLE DERIVATIVES AS WNT SIGNALING PATHWAY INHIBITORS

The present invention relates to compounds of formula (I), to processes for their preparation, to pharmaceutical formulations containing such compounds and to their use in therapy: Such compounds find particular use in the treatment and/or prevention of conditions or diseases which are affected by over-activation of signaling in the Wnt pathway and increased presence of nuclear β-catenin. For example, these may be used in preventing and/or retarding proliferation of tumor cells and metastasis, for example carcinomas such as colon carcinomas.