1380776-10-2Relevant academic research and scientific papers
Indium Trichloride (InCl3) Catalyzed Synthesis of Fused 7-Azaindole Derivatives Using Domino Knoevenagel-Michael Reaction
Dongare, Sakharam B.,Chavan, Hemant V.,Surwase, Datta N.,Bhale, Pravin S.,Mule, Yoginath B.,Bandgar, Babasaheb P.
, p. 323 - 330 (2016)
An efficient and high yielding methodology developed for the synthesis of fused 7-azaindole derivatives via one pot multicomponent assembly process of cyclic 1,3-dicarbonyls with substituted aldehydes and 5-amino-1-tert-butyl-1H-pyrrole-3-carbonitrile. The transformation occurs via domino Knoevenagel- Michael reaction followed by intramolecular cyclization in the presence of catalytic amount of InCl3 (10 mol%). Mild reaction conditions, easy isolation of products, and good to excellent yields in a shorter period of time are the silent features of present methodology. Structures of all the newly prepared compounds have been corroborated by various spectroscopic methods.
One-pot, three-component synthesis of 7-azaindole derivatives from N-substituted 2-amino-4-cyanopyrroles, various aldehydes, and active methylene compounds
Vilches-Herrera, Marcelo,Knepper, Ingo,De Souza, Nayane,Villinger, Alexander,Sosnovskikh, Vyacheslav Ya.,Iaroshenko, Viktor O.
experimental part, p. 434 - 441 (2012/09/10)
An efficient and practical route to 7-azaindole framework has been developed by one-pot, three-component cyclocondensation of N-substituted 2-amino-4-cyanopyrroles, various aldehydes, and active methylene compounds in ethanol or acetic acid at reflux. Rea
