13808-26-9

Upstream product

• 109-01-3 1-methyl-piperazine 
• 75-09-2 dichloromethane 
• 536-74-3 phenylacetylene 
• 50-00-0 formaldehyd 
• 6738-06-3 phenylethynylmagnesium bromide 
• 19212-84-1 1-[(4-methylpiperazin-1-yl)methyl]-1H-1,2,3-benzotriazole 

Relevant academic research and scientific papers

Synthesis, structure and multifunctional catalytic properties of a Cu(i)-coordination polymer with outer-hanging CuBr2

A 1D Cu(i)-coordination polymer [(CuL1)(CuBr2), 1] carrying external copper bromide moieties was synthesized. The outer-hanging [CuBr2]- moiety is attached to the 1D Cu(i)-CP backbone via a Cu?Cu bonding interaction, which makes it look like a coordination polymer supported CuBr2 species. 1 exhibits excellent multifunctional catalytic activity for phenol acetylation, A3-coupling (aldehyde-alkyne-amine) and styrene oxide methanolysis reactions. Its heterogeneous catalytic nature was confirmed by solution leaching experiment and it can be reused without significant loss of its catalytic activity and selectivity for the above reactions.

Microwave-assisted copper(I) catalyzed A3-coupling reaction: Reactivity, substrate scope and the structural characterization of two coupling products

The application of highly efficient catalyst [{Cu(μ ? I)2Cu}(PPh3)4] for the synthesis of biologically and pharmaceutically important propargylamine derivatives through microwave assisted A3-coupling reaction is

Self-Assembled Cyclophane-Type Copper(I) Complexes of 2,4,6-Tris(diphenylphosphino)-1,3,5-triazine and Their Catalytic Application

The triazine-based trisphosphine, 2,4,6-tris(diphenylphosphino)-1,3,5-triazine (1) was prepared in improved yield by reacting cyanuric chloride with 3 equiv of trimethylsilyldiphenylphosphine. The solid-state structure of 1 showed short intermolecular P··

Nickel-catalyzed three-component coupling reaction of terminal alkynes, dihalomethane and amines to propargylamines

Direct C - H and C - halogen activation is an important and practical task in C - C, C - N bond formation reactions using alkynes. Propargylic amines are synthetically versatile intermediates for the preparation of many nitrogen-containing biologically ac

Postsynthetic modification of metal-organic framework as a highly efficient and recyclable catalyst for three-component (aldehyde-alkyne-amine) coupling reaction

A MOF-supported Cu(I) catalyst bearing N,O-chelating ligand was prepared through postsynthetic modification of IRMOF-3 and used as an efficient heterogeneous catalyst for three-component coupling reaction of aldehyde, alkyne, and amine. The catalyst exhib

A simple method for the preparation of propargylamines using molecular sieve modified with copper(II)

A new, heterogeneous, 4 A molecular sieve-supported copper(ii) catalyst was developed and was used successfully in the A3 coupling of alkynes, aldehydes and amines under simple reaction conditions.

Synthesis and antimicrobial activity of N-alkyl and N-aryl piperazine derivatives

A series of substituted piperazine derivatives have been synthesized and tested for antimicrobial activity. The antibacterial activity was tested against Staphylococcus aureus (MTCCB 737), Pseudomonas aeruginosa (MTCCB 741), Streptomyces epidermidis (MTCCB 1824) and Escherichia coli (MTCCB 1652), and antifungal activity against Aspergillus fumigatus, Aspergillus flavus and Aspergillus niger. All synthesized compounds showed significant activity against bacterial strains but were found to be less active against tested fungi. In vitro toxicity tests demonstrated that compounds 4d and 6a showed very less toxicity against human erythrocytes.