1380920-95-5

Upstream product

• 1147207-18-8 4-chloro-N-methyl-2-nitro-5-(3-(trifluoromethyl)piperidin-1-yl)aniline 
• 1242268-43-4 tert-butyl 4-chloro-3-isothiocyanatobenzylcarbamate 
• 1380920-94-4 5-chloro-2-methylamino-4-(3-(trifluoromethyl)piperidin-1-yl)aniline 
• 107342-18-7 4,5-dichloro-N-methyl-2-nitrobenzenamine 
• 180081-30-5 N-(3-amino-4-chlorophenylmethyl)carbamic acid t-butyl ester 
• 180081-29-2 N-(4-chloro-3-nitrophenylmethyl)carbamic acid t-butyl ester 
• 116599-39-4 (4-chloro-3-nitrophenyl)methanamine hydrochloride 
• 2339-78-8 1,2-dichloro-4-fluoro-5-nitrobenzene 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1380920-96-6 4-chloro-3-[5-chloro-1-methyl-6-(3-(trifluoromethyl)piperidin-1-yl)-1H-benzo[d]imidazol-2-ylamino]benzylamine 

Relevant academic research and scientific papers

NOVEL COMPOUNDS

This invention relates to compounds of formula I their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), to pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, M, W, R1, R2, R3, R4, R6, R2, R7, R8, R9, Ra, Rb have meanings given in the description.

2 -AMINOBENZ IMIDAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF INFLAMMATION

This invention relates to compounds of formula (I), their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the 10 treatment and/or prevention of inflammatory diseases and associated conditions. A, M, W, R1, R2, R3, R4, R6, R2,R7, R8, R9, Ra, Rb have meanings given in the description.