13811-11-5

Usage

Uses

Used in Pharmaceutical Industry:
3,5-Diiodo-4-hydroxyphenylpropionic acid is used as an intermediate in the synthesis of 3,3’,5-Triiodo Thyropropionic Acid (T795410), which is a thyroid hormone analog. This hormone analog serves as an antilipemic, helping to regulate lipid levels in the body and potentially treating conditions related to high lipid levels, such as hyperlipidemia.
Additionally, given its role in the synthesis of thyroid hormone analogs, 3,5-diiodo-4-hydroxyphenylpropionic acid may also be utilized in the development of medications for other thyroid-related disorders, such as hypothyroidism or hyperthyroidism. Its specific application would depend on the requirements of the pharmaceutical compound being synthesized and the targeted health condition.

InChI:InChI=1/C9H8I2O3/c10-6-3-5(1-2-8(12)13)4-7(11)9(6)14/h3-4,14H,1-2H2,(H,12,13)

Upstream product

• 501-97-3 4-hydroxyphenylpropionic acid 

Downstream Products

• 189447-39-0 3-(4-hydroxy-3,5-diiodo-phenyl)-propionic acid ethyl ester 
• 53937-19-2 3-(p-hydroxy-m-iodo-phenyl)propionic acid 
• 39846-93-0 3-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]-propionic acid 
• 1449075-85-7 4-hydroxyphenethyl 3-(4-hydroxy-3,5-diiodophenyl)-propanoate 
• 1221279-42-0 C₂₁H₂₀I₄O₆ 
• 110972-54-8 C₁₃H₁₁I₂NO₅ 
• 1332500-06-7 methyl 3-(3,5-diiodo-4-methoxyphenyl)propanoate 
• 1332500-05-6 methyl 3-(4-(2-ethylhexyloxy)-3,5-diiodophenyl)propanoate 
• 264265-63-6 methyl 3-(4-hydroxy-3,5-diiodophenyl)propanoate 
• 848915-24-2 3,5-diiododesaminotyrosyl-tyrosine ethyl ester 

Relevant academic research and scientific papers

CARBONIC ANHYDRASE IX INHIBITOR CONJUGATES AND USES THEREOF

The present disclosure relates to compositions and methods of carbonic anhydrase IX inhibitors. The present disclosure also relates to targeting conjugates of carbonic anhydrase IX inhibitors as therapeutics and imaging agents. The present disclosure also relates to the use of targeting conjugates of carbonic anhydrase IX inhibitors in imaging methods and cancer therapy.

Amphiphilic ??-conjugated poly(m-phenylene) photosensitizer for the Eu3+ ion: The role of macromolecular chain aggregation on the color tunability of lanthanides

Here, we report new carboxylic functionalized poly(phenylene)s and their oligomers as selective and efficient photosensitizers for Eu3+ ions. Palladium-catalyzed Suzuki polycondensation was developed for the synthesis of carboxylic functionaliz

N-substituted monomers and polymers

Biocompatible, bioresorbable polymers comprising a plurality of monomeric repeating units containing an amide group, wherein said amide groups are N-substituted and the N-substituent and degree of N-substitution are effective to lower the melt viscosity,

PROCESS FOR PRODUCTION OF PHENOL DERIVATIVES SUBSTITUTED WITH IODINE AT ORTHO POSITION

A process in which a phenol derivative is iodinated to produce a 2-iodophenol or 2,6-diiodophenol derivative substituted with iodine at an ortho position thereof is provided, which does not require any step of recovery of iodine but can produce it at low cost, in high yield and with high quality. A phenol derivative is mixed with a pyridine and hydrogen peroxide or iodic acid as an oxidizing agent, and reacted with molecular iodine. As a result, iodination can be performed very efficiently with iodine in an amount close to the theoretical amount relative to the phenol derivative, and the 2-iodophenol or 2,6-diiodophenol derivative can be obtained in high yield and with high quality.

Radiopaque polymeric stents

Preferred embodiments of the present invention relate to polymeric medical devices, such as stents. More particularly, the polymeric compositions disclosed herein comprise halogen-containing, tyrosine-derived diphenols, optionally in conjunction with othe

Method to treat chronic heart failure and/or elevated cholesterol levels using 3,5-diiodothyropropionic acid and method to prepare same

Applicants' invention includes a method to treat a patient having congestive heart failure by administering a therapeutically effective amount of 3,5-diidothyropropionic acid. Applicants' invention further includes a method to lower cholesterol blood levels of a patient by administering a therapeutically effective amount of 3,5-diidothyropropionic acid. Applicants' invention further includes a synthetic method to prepare 3,5-diidothyropropionic acid.

Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor

Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and