138117-13-2

Upstream product

• 22118-09-8 2-bromoacetyl chloride 
• 1072-86-2 (1R,2R)-trans-1,2-cyclohexanediol 

Downstream Products

• 156256-43-8 (1'R,2'R,5R)-2'-hydroxycyclohexyl (E)-5,9-dimethyl-2,8-decadienoate 
• 156170-88-6 (1'R,2'R,5S)-2'-hydroxycyclohexyl (E)-5,9-dimethyl-2,8-decadienoate 
• 138117-16-5 (E)-15-(Pyridin-2-ylsulfanylcarbonyl)-pentadec-2-enoic acid (1R,2R)-2-hydroxy-cyclohexyl ester 
• 138117-11-0 (R)-2-Methyl-15-oxo-cyclopentadecanecarboxylic acid (1R,2R)-2-hydroxy-cyclohexyl ester 
• 156170-87-5 (1'R,2'R)-2'-hydroxycyclohexyl diethylphosphonoacetate 
• 138117-14-3 (Triphenyl-λ⁵-phosphanylidene)-acetic acid (1R,2R)-2-hydroxy-cyclohexyl ester 

Relevant academic research and scientific papers

Synthetic approach to 1,3-polymethyl function based on diastereoselective conjugate addition

A new method for diastereo- and enantioselective preparation of 1,3- polymethyl functions was studied. The reaction of (1'R,2'R,5R)-(2E)-2'- hydroxycyclohexyl 5,9-dimethyl-2,8-decadienoate (6) with Me2 CuLi afforded a diastereomeric mixture of conjugate addition products ((3R,5R)-9 and (3S,5R)- 9) in a ratio of 77 to 23.

Asymmetric Syntheses of (R)-(-)-Muscone based on Diastereoselective Conjugate Addition

(R)-(-)-Muscone was synthesized in a stereocontrolled manner via the stereoselective conjugate addition to a cyclic α,β-unsatureted ester of (R,R)-cyclohexane-1,2-diol accompanied by spontaneous Dieckmann condensation.