
Chemical and Pharmaceutical Bulletin p. 1652 - 1654 (1993)
Update date:2022-09-26
Topics:
Ogawa
Suemune
Sakai
A new method for diastereo- and enantioselective preparation of 1,3- polymethyl functions was studied. The reaction of (1'R,2'R,5R)-(2E)-2'- hydroxycyclohexyl 5,9-dimethyl-2,8-decadienoate (6) with Me2 CuLi afforded a diastereomeric mixture of conjugate addition products ((3R,5R)-9 and (3S,5R)- 9) in a ratio of 77 to 23.
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