1381809-31-9Relevant academic research and scientific papers
Enantioselective intramolecular formal [2 + 4] annulation of acrylates and α,β-unsaturated imines catalyzed by amino acid derived phosphines
Jin, Zhichao,Yang, Ruojie,Du, Yu,Tiwari, Bhoopendra,Ganguly, Rakesh,Chi, Yonggui Robin
, p. 3226 - 3229 (2012/08/08)
The first chiral phosphine-catalyzed activation of acrylates for intramolecular formal [2 + 4] reactions with unsaturated imines is described. The catalytic reactions afford N-heterocycles with exceptionally high diastereo- and enantioselectivities. The [2 + 4] products are amenable for further transformations to useful molecules such as chiral piperidines and multicyclic structures.
