1381867-10-2Relevant academic research and scientific papers
Synthesis of oxacyclic dienes via ring-closing enyne metathesis: Difference in construction of eight-membered rings
Zhang, Lin-Lin,Zhang, Wen-Zhen,Ren, Xiang,Tan, Xin-Yan,Lu, Xiao-Bing
, p. 3389 - 3392 (2012)
A series of oxacyclic diene compounds, especially eight-membered products bearing a single oxygen atom which have not been reported previously, were successfully synthesized via ring-closing enyne metathesis using the second-generation Grubbs catalyst. In contrast to the construction of the five-membered rings, completely opposite substrate selectivity that methyl substituted internal alkyne showed much higher reactivity than terminal alkyne was observed in building eight-membered ring derivatives.
