1381870-48-9

Upstream product

• 126728-20-9 2,4-dichloropyrido[2,3-d]pyrimidine 
• 107099-99-0 2,5-dimethoxyphenylboronic acid 

Downstream Products

• 1381870-58-1 4-(2,5-dimethoxyphenyl)-2-(4-methoxyphenyl)pyrido[2,3-d]pyrimidine 

Relevant academic research and scientific papers

Convenient synthesis of 2,4-disubstituted pyrido[2,3-d]pyrimidines via regioselective palladium-catalyzed reactions

A novel and effective route for the synthesis of 2,4-disubstituted pyrido[2,3-d]pyrimidines III is reported starting from the corresponding 2,4-dichloropyridopyrimidine 1 through regioselective functionalization palladium-catalyzed C-C coupling reactions, by two successive palladium-catalyzed reactions involving an original regioselective chlorine discrimination. Alternatively, type III compounds were elaborated from 2 by C-2 chlorine further displacement of the C-4 isopropylsulfanyl group, which acted as a temporary C-4 protecting group. Further Suzuki-Miyaura cross-coupling reactions led to C-2 and C-4 disubstituted compounds.