1381883-30-2Relevant academic research and scientific papers
Pyrazoline compounds thereof in the preparation of the application of the anti-cancer therapeutic drug
-
Paragraph 0019; 0026; 0027; 0028, (2016/10/08)
The invention relates to a pyrazoline derivative which is characterized by having a general formula shown in the specification. In the structural formula, R1 is pyridyl, 6-chloropyridyl, 6-methylpyridyl, 2-chloro, 6-methyl-pyridyl, 5-bromopyridyl or 2-chl
Synthesis, biological evaluation and 3D-QSAR studies of novel 4,5-dihydro-1H-pyrazole niacinamide derivatives as BRAF inhibitors
Li, Cui-Yun,Li, Qing-Shan,Yan, Li,Sun, Xiao-Guang,Wei, Ran,Gong, Hai-Bin,Zhu, Hai-Liang
, p. 3746 - 3755 (2012/08/28)
A series of novel 4,5-dihydropyrazole derivatives containing niacinamide moiety as potential V600E mutant BRAF kinase (BRAFV600E) inhibitors were designed and synthesized. Results of the bioassays against BRAF V600E and WM266.4 human
