138200-52-9

Upstream product

• 138200-45-0 2-((S)-1-Methoxycarbonyl-2-methyl-propylamino)-cyclohex-1-enecarboxylic acid methyl ester 
• 94-36-0 dibenzoyl peroxide 
• 138200-44-9 2-((S)-1-Ethoxycarbonyl-2-methyl-propylamino)-cyclohex-1-enecarboxylic acid methyl ester 
• 138200-46-1 2-((R)-1-tert-Butoxycarbonyl-2-methyl-propylamino)-cyclohex-1-enecarboxylic acid methyl ester 
• 98-88-4 benzoyl chloride 
• 41302-34-5 2-(methoxycarbonyl)cyclohexanone 

Relevant academic research and scientific papers

Oxidation of 1,3-dicarbonyl compounds using (camphorylsulfonyl)oxaziridines

The oxidation of 1,3-dicarbonyl compounds with (camphorylsulfonyl)oxaziridines 2 was studied in both cyclic and acyclic systems. Two reaction pathways were identified: Enolate α-hydroxylation and a novel Baeyer-Villiger type oxidation. The Baeyer-Villiger oxidation product was observed only for the ketones and arises via rearrangement of an alkoxy epoxide. Synthetically useful ee's (82-95%) were observed only for enolates of β-ketoesters where the keto group is part of a 6-membered ring.

Asymmetric oxidation of β-ketoesters with benzoyl peroxide; enantioselective formation of protected tertiary alcohols

Asymmetric oxidation of β-ketoesters by the benzoyl peroxide quench of their lithioenamines formed with (S)-valine t-butyl esters has been accomplished with good enantioselectivity for the formation of tertiary benzoate esters. This procedure thus enables generation of tertiary alcohols in protected form.