1382034-64-1

Basic information

• Product Name: C₃₅H₄₀ClN₃O₄S
• Synonyms: C₃₅H₄₀ClN₃O₄S
• CAS NO: 1382034-64-1
• Molecular Weight: 634.239
• Mol File: 1382034-64-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₅H₄₀ClN₃O₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₅H₄₀ClN₃O₄S(1382034-64-1)
• EPA Substance Registry System: C₃₅H₄₀ClN₃O₄S(1382034-64-1)

Safety Data

• Hazardous Substances Data: 1382034-64-1(Hazardous Substances Data)

Upstream product

• 36964-33-7 (3-bromotricyclo[3.3.1.1^3,7]dec-1-yl)methanol 
• 21816-08-0 3-bromoadamantane-1-carboxylic acid 
• 1382034-59-4 (3-bromoadamantan-1-yl)methanesulfonamide 
• 916204-05-2 4-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)benzoic acid 
• 1382034-60-7 (3-hydroxyadamantan-1-yl)methanesulfonamide 

Relevant articles and documents

Lipophilic isosteres of a π-π Stacking interaction: New inhibitors of the Bcl-2-Bak protein-protein interaction

The discovery of new Bcl-2 protein-protein interaction antagonists is described. We replaced the northern fragment of ABT737 (π-π stacking interactions) with structurally simplified hydrophobic cage structures with much reduced conformational flexibility and rotational freedom. The binding mode of the compounds was elucidated by X-ray crystallography, and the compounds showed excellent oral bioavailability and clearance in rat PK studies.