138207-66-6

Upstream product

• 501-53-1 benzyl chloroformate 
• 110690-36-3 L-Lysinol 
• 83173-67-5 N_α,N_ξ-di-Cbz-L-lysine ethyl ester 
• 3844-53-9 L-lysine ethyl ester dihydrochloride 
• 405-39-0 N,N'-di-[(phenylmethoxy)carbonyl]-L-lysine 
• 21160-83-8 N_α,N_ε-bis(carbobenzyloxy)-L-lysine N-hydroxysuccinimide ester 
• 55592-84-2 Nε-Cbz-lysine 
• 137649-64-0 N,N-bis-Cbz-L-lysinol 

Downstream Products

• 139033-50-4 Z-Lysψ(CH2NH)Trp-OMe 
• 138207-74-6 (2S,3R)-bis(N-benzyloxycarbonyl)-3,7-diamino-2-hydroxyheptanoic acid methyl ester 
• 138207-73-5 (2R,3R)-bis(N-benzyloxycarbonyl)-3,7-diamino-2-hydroxyheptanoic acid methyl ester 
• 1432584-79-6 (S)-tert-butyl 2-((S)-2,6-bis(((benzyloxy)carbonyl)amino)hexanamido)propanoate 
• 84765-39-9 (S)-tert-butyl 2-formamidopropanoate 
• 1432584-78-5 (S,Z)-N-((S)-2,6-bis(((benzyloxy)carbonyl)amino)hexylidene)-1-(tert-butoxy)-1-oxopropan-2-amine oxide 
• 138207-68-8 (2R,3S)-bis(N-benzyloxycarbonyl)-3,7-diamino-2-hydroxyheptanoic acid methyl ester 
• 138207-67-7 (2S,3S)-bis(N-benzyloxycarbonyl)-3,7-diamino-2-hydroxyheptanoic acid methyl ester 
• 1311399-83-3 C₂₅H₂₇N₃O₇ 
• 137649-82-2 {4-[(4S,5R,4'S,5'R)-4'-(4-Benzyloxycarbonylamino-butyl)-2,2'-dioxo-3,3'-bis-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyl)-[5,5']bioxazolidinyl-4-yl]-butyl}-carbamic acid benzyl ester 
• 184634-93-3 (R)-1-((S)-2,6-Bis-benzyloxycarbonylamino-hexyl)-pyrrolidine-2-carboxylic acid 
• 184635-12-9 (S)-1-((S)-2,6-Bis-benzyloxycarbonylamino-hexyl)-pyrrolidine-2-carboxylic acid 

Relevant academic research and scientific papers

Rigid spiroethers targeting the decoding center of the bacterial ribosome

Continuing our efforts towards understanding the principles governing ribosomal recognition and function, we have synthesized and evaluated a series of diversely functionalized 5,6-, 6,6- and 7,6-spiroethers. These compounds successfully mimic natural aminoglycosides regarding their binding to the decoding center of the bacterial ribosome. Their potential to inhibit prokaryotic protein production in vitro along with their antibacterial potencies have also been examined.

Peptide fragment coupling using a continuous-flow photochemical rearrangement of nitrones

Go with the flow: A general approach for amide bond formation by way of a continuous-flow photochemical rearrangement of nitrones was described (see scheme). Simple aryl-alkyl amide bonds as well as complex peptide bonds were constructed efficiently with a residence time less than 20minutes. A tetrapeptide was synthesized in this way and the method could be applied to peptide fragment coupling. Copyright

Procedure for the oxidation of β-amino alcohols to α-amino aldehydes

A novel procedure for the mild oxidation of β-amino alcohols to α-amino aldehydes using commercially available manganese(IV) oxide is reported. There are several important advantages of the new method, such as high enantiopurity of the reaction and the absence of either over-oxidation or any reaction by-products during the process. A number of N-protected L-α-amino aldehydes was obtained. All new compounds were characterized by their NMR spectra and optical rotation data. Georg Thieme Verlag Stuttgart.

Synthesis and antinociceptive activity of some novel nonpeptide derivatives of interleukin-1β (193-195) sequence

The synthesis of a new series of nonpeptide derivatives of interleukin- 1β sequence is described. Compounds have been investigated for their relative activity regarding antinociception and suppression of inflammation. Several compounds with R1(

Pinacol cross coupling of 2-[N-(alkoxycarbonyl)amino] aldehydes and aliphatic aldehydes by [V2Cl3(THF)6]2[Zn2Cl 6]. Synthesis of syn,syn-3-[N-(alkoxycarbonyl)amino] 1,2-diols

Slow addition of 2-[N-(alkoxycarbonyl)amino] aldehydes to mixtures of [V2Cl3(THF)6]2[Zn2Cl 6] and aliphatic aldehydes gave syn,syn-3-[N-(alkoxycarbonyl)amino] 1,2-diols in good yield and high enantiomeric purity (>99:1). The alkyl group of the N-alkoxycarbonyl was shown to influence the yield: Me > allyl > Bn > t-Bu. Only the syn,syn diastereomer was observed (>20:1), except with N-Cbz-alaninal (10:1:1), O-benzyl-N-Cbz-serinal (7:1), and N-Cbz-prolinal (5:1 to 12:1). A new serinai derivative, N-Cbz-O-TBS-serinal, was cross coupled with n-pentadecanal to give a derivative of xylo-D-C18-phytosphingosine.

Pinacol Homocoupling of (S)-2- Aldehydes by 2. Synthesis of C2-Symmetric (1S,2R,3R,4S)-1,4-Diamino 2,3-Diols

Six (S)-2- aldehydes 3a-f were homocoupled by 2 (1) to give C2-symmetric (1S,2R,3R,4S)-1,4-bis 2,3-diols 4a-f in good yield.High-yield conversions of the diols to biso