137649-64-0

Upstream product

• 56-87-1 L-lysine 
• 501-53-1 benzyl chloroformate 
• 3844-53-9 L-lysine ethyl ester dihydrochloride 
• 405-39-0 N,N'-di-[(phenylmethoxy)carbonyl]-L-lysine 
• 21160-83-8 N_α,N_ε-bis(carbobenzyloxy)-L-lysine N-hydroxysuccinimide ester 
• 83173-67-5 N_α,N_ξ-di-Cbz-L-lysine ethyl ester 
• 110690-36-3 L-Lysinol 

Downstream Products

• 138207-66-6 N^α,N^ε-bis(benzyloxycarbonyl)-D-lysinal 
• 137649-82-2 {4-[(4S,5R,4'S,5'R)-4'-(4-Benzyloxycarbonylamino-butyl)-2,2'-dioxo-3,3'-bis-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyl)-[5,5']bioxazolidinyl-4-yl]-butyl}-carbamic acid benzyl ester 
• 137649-70-8 (5S,6R,7R,8S)-1,5,8,12-Tetrakis-6,7-dodecanediol 

Relevant academic research and scientific papers

Phosphorylcholine compound Lys-PC containing propyl dimethicone and preparation method thereof

The invention discloses a phosphorylcholine compound Lys-PC containing propyl dimethicone and a preparation method thereof. The phosphorylcholine compound can be used as a surface treating agent or a raw material of the surface treating agent, can be directly used as a modifier for surfaces of various base materials or a chain extender and a cross-linking agent of modification of the base materials, can lower adsorption of protein, can improve the biocompatibility of high polymer materials by reducing adhesion and activation of blood platelets and has huge academic value and wide application prospects in the fields such as tissue engineering, controlled drug release, gene therapy and cosmetics. The steps are simple, the operation is convenient and the practicability is high.

Rigid spiroethers targeting the decoding center of the bacterial ribosome

Continuing our efforts towards understanding the principles governing ribosomal recognition and function, we have synthesized and evaluated a series of diversely functionalized 5,6-, 6,6- and 7,6-spiroethers. These compounds successfully mimic natural aminoglycosides regarding their binding to the decoding center of the bacterial ribosome. Their potential to inhibit prokaryotic protein production in vitro along with their antibacterial potencies have also been examined.

Procedure for the oxidation of β-amino alcohols to α-amino aldehydes

A novel procedure for the mild oxidation of β-amino alcohols to α-amino aldehydes using commercially available manganese(IV) oxide is reported. There are several important advantages of the new method, such as high enantiopurity of the reaction and the absence of either over-oxidation or any reaction by-products during the process. A number of N-protected L-α-amino aldehydes was obtained. All new compounds were characterized by their NMR spectra and optical rotation data. Georg Thieme Verlag Stuttgart.

Pinacol cross coupling of 2-[N-(alkoxycarbonyl)amino] aldehydes and aliphatic aldehydes by [V2Cl3(THF)6]2[Zn2Cl 6]. Synthesis of syn,syn-3-[N-(alkoxycarbonyl)amino] 1,2-diols

Slow addition of 2-[N-(alkoxycarbonyl)amino] aldehydes to mixtures of [V2Cl3(THF)6]2[Zn2Cl 6] and aliphatic aldehydes gave syn,syn-3-[N-(alkoxycarbonyl)amino] 1,2-diols in good yield and high enantiomeric purity (>99:1). The alkyl group of the N-alkoxycarbonyl was shown to influence the yield: Me > allyl > Bn > t-Bu. Only the syn,syn diastereomer was observed (>20:1), except with N-Cbz-alaninal (10:1:1), O-benzyl-N-Cbz-serinal (7:1), and N-Cbz-prolinal (5:1 to 12:1). A new serinai derivative, N-Cbz-O-TBS-serinal, was cross coupled with n-pentadecanal to give a derivative of xylo-D-C18-phytosphingosine.

Pinacol Homocoupling of (S)-2- Aldehydes by 2. Synthesis of C2-Symmetric (1S,2R,3R,4S)-1,4-Diamino 2,3-Diols

Six (S)-2- aldehydes 3a-f were homocoupled by 2 (1) to give C2-symmetric (1S,2R,3R,4S)-1,4-bis 2,3-diols 4a-f in good yield.High-yield conversions of the diols to biso