1382153-73-2

Basic information

• Product Name: (5R,6R)-1-benzyl-6-{(1'S)-3'-[(tert-butyldimethylsilyl)oxy]-1'-hydroxypropyl}-8,8-dimethyl-3,7,9-trioxa-1-azaspiro[4.5]decan-2-one
• Synonyms: (5R,6R)-1-benzyl-6-{(1'S)-3'-[(tert-butyldimethylsilyl)oxy]-1'-hydroxypropyl}-8,8-dimethyl-3,7,9-trioxa-1-azaspiro[4.5]decan-2-one
• CAS NO: 1382153-73-2
• Molecular Weight: 465.662
• Mol File: 1382153-73-2.mol

Chemical Properties

• CAS DataBase Reference: (5R,6R)-1-benzyl-6-{(1'S)-3'-[(tert-butyldimethylsilyl)oxy]-1'-hydroxypropyl}-8,8-dimethyl-3,7,9-trioxa-1-azaspiro[4.5]decan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (5R,6R)-1-benzyl-6-{(1'S)-3'-[(tert-butyldimethylsilyl)oxy]-1'-hydroxypropyl}-8,8-dimethyl-3,7,9-trioxa-1-azaspiro[4.5]decan-2-one(1382153-73-2)
• EPA Substance Registry System: (5R,6R)-1-benzyl-6-{(1'S)-3'-[(tert-butyldimethylsilyl)oxy]-1'-hydroxypropyl}-8,8-dimethyl-3,7,9-trioxa-1-azaspiro[4.5]decan-2-one(1382153-73-2)

Safety Data

• Hazardous Substances Data: 1382153-73-2(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 1382153-86-7 ethyl (4S,2E)-4-{(R)-4-[(S)-2-acetoxy-1-hydroxyethyl]-3-benzyl-2-oxooxazolidin-4-yl}-4-hydroxybut-2-enoate 
• 1382153-84-5 (5R,6S,8S,9R)-6-(acetoxymethyl)-1-benzyl-8,9-dihydroxy-3,7-dioxa-1-azaspiro [4.4]nonan-2-one 
• 1382153-82-3 (3aR,4'S,5S,6aR)-5-(acetoxymethyl)-3'-benzyl-2,2-dimethyldihydro-3aH-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one 
• 1382153-80-1 (3aR,4'S,5S,6aR)-3'-benzyl-5-(hydroxymethyl)-2,2-dimethyldihydro-3aH-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one 
• 1382153-78-7 (3aR,4'S,5S,6aR)-3'-benzyl-5-{[(tert-butyldimethylsilyl)oxy]methyl}-2,2-dimethyldihydro-3aH-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one 
• 1382153-98-1 (5R,6R)-1-benzyl-6-[(1'S)-1',3'-dihydroxypropyl]-8,8-dimethyl-3,7,9-trioxa-1-azaspiro[4.5]decan-2-one 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 1382153-75-4 (5R,6S)-1-benzyl-6-[(E)-3'-hydroxyprop-1'-enyl]-8,8-dimethyl-3,7,9-trioxa-1-azaspiro[4.5]decan-2-one 
• 1251959-23-5 (3aR,4'S,5S,6aR)-5-[(t-butyldimethylsilyloxy)methyl]-2,2-dimethyldihydro-3aH-spiro[furo[2,3-d][1,3]dioxole-6,4-oxazolidin]-2'-one 

Downstream Products

• 1382154-04-2 (5R,6R)-1-benzyl-6-{(1'R)-3'-[(tert-butyldimethylsilyl)oxy]-1'-hydroxypropyl}-8,8-dimethyl-3,7,9-trioxa-1-azaspiro[4.5]decan-2-one 
• 1382154-06-4 (4aS,8R,8aR)-5-benzyl-8-{2'-[(tert-butyldimethylsilyl)oxy]ethyl}-4a-(benzyloxymethyl)-2,2-dimethyltetrahydro-[1,3]dioxino[5,4-d][1,3]oxazin-6(4H)-one 
• 1382154-10-0 (4aS,8R,8aR)-5-benzyl-8-{2'-[(tert-butyldimethylsilyl)oxy]ethyl}-4a-(hydroxymethyl)-2,2-dimethyltetrahydro-[1,3]dioxino[5,4-d][1,3]oxazin-6(4H)-one 
• 1382153-71-0 (4aS,8R,8aR)-5-benzyl-8-{2'-[(tert-butyldimethylsilyl)oxy]ethyl}-2,2-dimethyl-6-oxohexahydro-[1,3]dioxino[5,4-d][1,3]oxazin-4a-carboxylic acid 
• 1382154-12-2 methyl (4aS,8R,8aR)-5-benzyl-8-{2'-[(tert-butyldimethylsilyl)oxy]ethyl}-2,2-dimethyl-6-oxohexahydro-[1,3]dioxino[5,4-d][1,3]oxazin-4a-carboxylate 
• 1382154-08-6 C₁₈H₂₅NO₆ 

Relevant articles and documents

A stereoselective synthesis of an α-substituted α-amino acid as a substructure for the construction of myriocin

A synthetic route to the protected quaternary α-amino acid 2 with a hydroxylated side chain has been achieved. The key transformations are the diastereoselective substrate-controlled epoxidation of allylic alcohol 4; a highly stereoselective oxidation-reduction protocol, and the excellent regioselective isomerization of the oxazolidinone ring to give an oxazinanone skeleton in derivative 3. The carboxylic acid 2 obtained represents the polar substructure, which is present in myriocin 1.