1382153-75-4

Upstream product

• 1251959-23-5 (3aR,4'S,5S,6aR)-5-[(t-butyldimethylsilyloxy)methyl]-2,2-dimethyldihydro-3aH-spiro[furo[2,3-d][1,3]dioxole-6,4-oxazolidin]-2'-one 
• 1382153-78-7 (3aR,4'S,5S,6aR)-3'-benzyl-5-{[(tert-butyldimethylsilyl)oxy]methyl}-2,2-dimethyldihydro-3aH-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one 
• 1382153-80-1 (3aR,4'S,5S,6aR)-3'-benzyl-5-(hydroxymethyl)-2,2-dimethyldihydro-3aH-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one 
• 1382153-82-3 (3aR,4'S,5S,6aR)-5-(acetoxymethyl)-3'-benzyl-2,2-dimethyldihydro-3aH-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one 
• 1382153-84-5 (5R,6S,8S,9R)-6-(acetoxymethyl)-1-benzyl-8,9-dihydroxy-3,7-dioxa-1-azaspiro [4.4]nonan-2-one 
• 1382153-86-7 ethyl (4S,2E)-4-{(R)-4-[(S)-2-acetoxy-1-hydroxyethyl]-3-benzyl-2-oxooxazolidin-4-yl}-4-hydroxybut-2-enoate 
• 1382153-88-9 (4R)-3-benzyl-4-[(1S,2E)-1,4-dihydroxybut-2-enyl]-4-[(1S)-1,2-dihydroxyethyl]oxazolidin-2-one 
• 100-39-0 benzyl bromide 

Downstream Products

• 1382153-94-7 (5R,6R)-1-benzyl-6-[(2'S,3'S)-3'-(hydroxymethyl)oxiran-2'-yl]-8,8-dimethyl-3,7,9-trioxa-1-azaspiro[4.5]decan-2-one 
• 1382153-92-5 (5R,6R)-1-benzyl-6-[(2'R,3'R)-3'-(hydroxymethyl)oxiran-2'-yl]-8,8-dimethyl-3,7,9-trioxa-1-azaspiro[4.5]decan-2-one 
• 1382153-96-9 (5R,6R)-1-benzyl-6-[(2'S,3'S)-3'-(trityloxymethyl)oxiran-2'-yl]-8,8-dimethyl-3,7,9-trioxa-1-azaspiro[4.5]decan-2-one 
• 1382153-98-1 (5R,6R)-1-benzyl-6-[(1'S)-1',3'-dihydroxypropyl]-8,8-dimethyl-3,7,9-trioxa-1-azaspiro[4.5]decan-2-one 
• 1382154-00-8 (5R,6R)-1-benzyl-6-[(1'S)-1',3'-diacetoxypropyl]-8,8-dimethyl-3,7,9-trioxa-1-azaspiro[4.5]decan-2-one 
• 1382153-73-2 (5R,6R)-1-benzyl-6-{(1'S)-3'-[(tert-butyldimethylsilyl)oxy]-1'-hydroxypropyl}-8,8-dimethyl-3,7,9-trioxa-1-azaspiro[4.5]decan-2-one 
• 1382154-04-2 (5R,6R)-1-benzyl-6-{(1'R)-3'-[(tert-butyldimethylsilyl)oxy]-1'-hydroxypropyl}-8,8-dimethyl-3,7,9-trioxa-1-azaspiro[4.5]decan-2-one 
• 1382154-06-4 (4aS,8R,8aR)-5-benzyl-8-{2'-[(tert-butyldimethylsilyl)oxy]ethyl}-4a-(benzyloxymethyl)-2,2-dimethyltetrahydro-[1,3]dioxino[5,4-d][1,3]oxazin-6(4H)-one 
• 1382154-10-0 (4aS,8R,8aR)-5-benzyl-8-{2'-[(tert-butyldimethylsilyl)oxy]ethyl}-4a-(hydroxymethyl)-2,2-dimethyltetrahydro-[1,3]dioxino[5,4-d][1,3]oxazin-6(4H)-one 
• 1382153-71-0 (4aS,8R,8aR)-5-benzyl-8-{2'-[(tert-butyldimethylsilyl)oxy]ethyl}-2,2-dimethyl-6-oxohexahydro-[1,3]dioxino[5,4-d][1,3]oxazin-4a-carboxylic acid 
• 1382154-12-2 methyl (4aS,8R,8aR)-5-benzyl-8-{2'-[(tert-butyldimethylsilyl)oxy]ethyl}-2,2-dimethyl-6-oxohexahydro-[1,3]dioxino[5,4-d][1,3]oxazin-4a-carboxylate 
• 1382154-08-6 C₁₈H₂₅NO₆ 

Relevant academic research and scientific papers

A stereoselective synthesis of an α-substituted α-amino acid as a substructure for the construction of myriocin

A synthetic route to the protected quaternary α-amino acid 2 with a hydroxylated side chain has been achieved. The key transformations are the diastereoselective substrate-controlled epoxidation of allylic alcohol 4; a highly stereoselective oxidation-reduction protocol, and the excellent regioselective isomerization of the oxazolidinone ring to give an oxazinanone skeleton in derivative 3. The carboxylic acid 2 obtained represents the polar substructure, which is present in myriocin 1.