138227-69-7

Basic information

• Product Name: 1-N-BOC-4-(4-AMINO-2-METHYLPHENOXY)PIPERIDINE
• Synonyms: 1-N-BOC-4-(4-AMINO-2-METHYLPHENOXY)PIPERIDINE;4-(4-AMINO-2-METHYL-PHENOXY)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-Boc-4-(4-amino-2-methylphenoxy)piperidine;tert-butyl 4-(4-amino-2-methylphenoxy)piperidine-1-carboxylate
• CAS NO: 138227-69-7
• Molecular Formula: C₁₇H₂₆N₂O₃
• Molecular Weight: 306.4
• Mol File: 138227-69-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 439.396°C at 760 mmHg
• Flash Point: 219.539°C
• Appearance: /
• Density: 1.123g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.549
• CAS DataBase Reference: 1-N-BOC-4-(4-AMINO-2-METHYLPHENOXY)PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-N-BOC-4-(4-AMINO-2-METHYLPHENOXY)PIPERIDINE(138227-69-7)
• EPA Substance Registry System: 1-N-BOC-4-(4-AMINO-2-METHYLPHENOXY)PIPERIDINE(138227-69-7)

Safety Data

• Hazardous Substances Data: 138227-69-7(Hazardous Substances Data)

Usage

General Description

1-N-BOC-4-(4-AMINO-2-METHYLPHENOXY)PIPERIDINE is a chemical compound with the molecular formula C19H30N2O3. It is a piperidine derivative with a BOC (tert-butyloxycarbonyl) protecting group attached to the nitrogen atom, and an amino group and a 4-amino-2-methylphenoxy substituent attached to the piperidine ring. 1-N-BOC-4-(4-AMINO-2-METHYLPHENOXY)PIPERIDINE is commonly used as a building block in organic synthesis, particularly in the development of pharmaceuticals and bioactive compounds. Its unique structure and functional groups make it a versatile intermediate for the synthesis of a variety of complex molecules with potential pharmacological or biological activity.

InChI:InChI=1/C17H26N2O3/c1-12-11-13(18)5-6-15(12)21-14-7-9-19(10-8-14)16(20)22-17(2,3)4/h5-6,11,14H,7-10,18H2,1-4H3

Upstream product

• 138227-68-6 1-tert-butyloxycarbonyl-4-(4-nitro-2methylphenyloxy)piperidine 
• 141-78-6 ethyl acetate 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 455-88-9 5-nitro-2-fluorotoluene 

Downstream Products

• 799242-51-6 4-[4-(6-fluoro-pyrido[3,4-d]pyrimidin-4-ylamino)-2-methyl-phenoxy]-piperidine-1-carboxylic acid tert-butyl ester 
• 337519-92-3 ethyl N-[4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3-methylphenyl]sulfamoylacetate 
• 807319-25-1 C₂₆H₃₄N₄O₅ 
• 807319-24-0 C₂₂H₂₆N₄O₃ 

Relevant articles and documents

Cinnamyl derivatives: Synthesis and factor Xa (FXa) inhibitory activities

To develop a potent and oral anticoagulant, a series of compounds with cinnamyl moiety was synthesized and their factor Xa (FXa) inhibitory activities were examined. As a result, some cinnamyl derivatives showed potent FXa inhibitory activities in vitro. Among them, compounds with substituent at the 3-position on the central benzene ring represented by (N-{4-[1-(acetimidoyl) piperidin-4-yloxy]-3-chlorophenyl}-N-[(E)-3-(3-amidinophenyl)-2-propenyl] sulfamoyl)acetic acid dihydrochloride (45b) and (N-{4-[1-(acetimidoyl)piperidin- 4-yloxy]-3-carbamoylphenyl}-N-[(E)-3-(3-amidinophenyl)-2-propenyl]sulfamoyl) acetic acid dihydrochloride (45j) exhibited potent FXa inhibitory activities with IC50 values of less than 10 nM in vitro. These compounds also showed potent anticoagulant activities both in vitro and ex vivo. Furthermore, these compounds exhibited no lethal toxicity (30 mg/kg, i.v.).

SUBSTITUTED HETEROCYCLES FOR THE TREATMENT OF ABNORMAL CELL GROWTH

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BENZAMIDINE DERIVATIVES

Benzamidine derivatives of formula (I) or pharmaceutically acceptable salts thereof exhibit excellent inhibitory activity against factor Xa and are useful for treating or preventing blood coagulation disorders: wherein R 1represents a hydrogen atom, a halogen atom, an alkyl group or a hydroxyl group; R 2represents a hydrogen atom, a halogen atom or an alkyl group, R 3represents a hydrogen atom, an optionally substituted alkyl group, an aralkyl group, an optionally substituted alkanoyl group or an optionally substituted alkylsulfonyl group, R 4and R 5 are the same as or different from each other and each represent a hydrogen atom, a halogen atom, an optionally substituted alkyl group, an alkoxy group, a carboxyl group, an alkoxycarbonyl group or an optionally substituted carbamoyl group, and R 6represents a substituted pyrrolidine group or substituted piperidine group.