138231-07-9Relevant articles and documents
Stereoselective methylations of bicyclic lactams derived from pyroglutamic acid
Armstrong,DeMattei
, p. 5749 - 5752 (1991)
Reaction of the lithium enolate of (-)7 with iodomethane provides a stereoselective synthesis of (2R,4S)-4-amino-2-methylpentanamide derivatives.
Compounding method for LCZ696 midbody
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Paragraph 0033; 0040; 0067; 0070, (2017/11/16)
The invention discloses a compounding method for a LCZ696 midbody. The compounding route is as follows: wherein R1 is Me, Et or i-Pr; X is Cl, Br or I; R2 is Ms, Ts or Tf. According to the compounding method for the LCZ696 midbody disclosed by the invention, the methylating difficulty is reduced, the midbody is configured and overturned through the consequent reaction, the proportion of the required configuration is greatly increased, the product yield, purity and use ratio are increased and the industrial large-scale production is benefited.
Substituted Piperidines that Increase P53 Activity and the Uses Thereof
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Page/Page column 88-89, (2008/06/13)
In its many embodiments, the present invention discloses novel compounds, as inhibitors of HDM2 protein, methods for preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of treatment, prevention, inhibition, of one or more diseases associated with the HDM2 protein or P53 using such compounds or pharmaceutical compositions.