138239-70-0

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 130515-58-1 5'-O-benzoyl-2'-deoxy-3'-O-mesyl-2',3'-secothymidine 
• 173961-35-8 Methanesulfonic acid (R)-3-hydroxy-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester 
• 130515-56-9 5'-benzoyl-2'-deoxy-2'-iodo-3'-O-mesyl-2',3'-secothymidine 
• 130515-54-7 O²,2'-anhydro-5'-O-benzoyl-3'-O-mesyl-2',3'-secothymidine 
• 130515-51-4 1-[1-(1-benzoyloxymethyl-2-hydroxyethoxy)-2-hydroxyethyl]thymine 
• 130515-49-0 5'-O-benzoylribothymidine dialdehyde 
• 120649-55-0 1-(5-O-benzoyl-β-D-ribofuranosyl)thymine 
• 126543-48-4 5'-O-benzoyl-2',3'-O-isopropylidene-5-methyluridine 
• 2073-43-0 2',3'-O,O-isopropylidene-5-methyluridine 
• 1463-10-1 5-Methyluridine 

Downstream Products

• 173961-42-7 Acetic acid (S)-3-{(S)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propylcarbamoyloxy}-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester 
• 173961-43-8 {(S)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl}-carbamic acid (S)-3-hydroxy-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester 
• 173961-41-6 Acetic acid (S)-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-3-(4-nitro-phenoxycarbonyloxy)-propyl ester 

Relevant academic research and scientific papers

OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF

The present disclosure provides modified oligonucleotides and compositions and methods thereof. In some embodiments, provided technologies comprise modified sugars and/or modified internucleotidic linkages. In some embodiments, the present disclosure provides technologies for preparing modified oligonucleotides. In some embodiments, the present disclosure provides chirally controlled oligonucleotide compositions and methods for their preparation and uses.

Oligonucleotides containing acyclic nucleoside analogues with carbamate internucleoside linkages

Synthesis of 2'-deoxy-2',3'-secothymidine t and its dimer t*t, where the two 2'-deoxy-2',3'-secothymidine t units are connected via a carbamate, =3'-NH-CO-O-5', internucleoside linkage has been achieved. These building blocks were protected in the 5'-posi