1382859-13-3

Upstream product

• 298-59-9 threo-methyl α-phenyl-α-(2-piperidyl)acetate hydrochloride 
• 160707-37-9 d-threo-2-phenyl-2-(piperidine-2-yl)acetamide 
• 1076192-92-1 2-phenyl-2-(piperidin-2-yl)acetic acid 
• 1556855-36-7 d-threo ritalinic acid dibenzoyl-L-tartrate 
• 113-45-1 dl-threo-methylphenidate 

Downstream Products

• 159701-30-1 C₁₃⁽¹¹⁾CH₁₉NO₂ 

Relevant academic research and scientific papers

Synthesis and pharmacology of ethylphenidate enantiomers: The human transesterification metabolite of methylphenidate and ethanol

Ethanol elevates methylphenidate (1) plasma concentrations and yields the metabolite ethylphenidate (2). The therapeutic implications are tinder investigation. The IC50 for dopamine reuptake inhibition by (+)-2 was 27 nM compared to 367 nM for cocaine and 1730 nM for (-)-2. Binding selectivity for dopamine versus norepinephrine transporters was greater for (+)-2 than for cocaine. Intraperitoneal (+)-2 was approximately half as active as (+)-1 in stimulating mouse motor activity at 5 mg/kg, but (+)-2 was as active as (+)-1 at 10 mg/kg.

A PROCESS FOR THE PREPARATION OF D-THREO-RITALINIC ACID SALTS VIA NOVEL SALTS OF INTERMEDIATE THEREOF

The present invention relates to a process for the preparation of d-threo-ritalinic acid salt thereof. More particularly, the present invention relates a process for the preparation of d-threo-ritalinic acid salt via novel organic salts of intermediate thereof.

AN IMPROVED PROCESS FOR - THE PREPARATION OF DEXMETHYLPHENIDATE HYDROCHLORIDE.

The present invention relates to an improved process for the preparation of Dexmethylphenidate hydrochloride of formula (A). More particularly, the present invention relates to an improved process for the preparation of Dexmethylphenidate hydrochloride of formula (A) and its intermediate d-threo ritalinic acid hydrochloride of formula (III).

IMPROVED PROCESS FOR THE PREPARATION OF D-THREO-RITALINIC ACID HYDROCHLORIDE BY RESOLUTION OF DL-THREO-RITALINIC ACID USING CHIRAL CARBOXYLIC ACID

The invention disclosed in this application relates to an improved process for the manufacture of d-threo-ritalinic acid hydrochloride and l-threo-ritalinic acid hydrochloride in an optically pure form by the resolution of dl-threo-ritalinic acid using a chiral carboxylic acid The d-threo-ritalinic acid hydrochloride prepared by the process of the present invention on esterif?cation gives d-threo-methylphenidate, a very well known CNS stimulant.

METHOD FOR THE PRODUCTION OF D-THREO-2-PHENYL-2-PIPERIDINE-2-YL ACETATES

Disclosed is a method for producing d-threo-[R(R*,R*)]-2-phenyl-2-piperidine-2-yl acetate and the acid addition salts thereof by converting d-threo-[R(R*,R*)]-2-phenyl-2-piperidine-2-yl ethanoic acid or an acid addition salt thereof into the corresponding

RESOLUTION OF RITALINIC ACID SALT

A process for preparing an enantiomerically-enriched form of threo-ritalinic acid, which comprises resolving a mixture of enantiomers of a salt of the acid, said salt being formed with an achiral acid or base, using a chiral resolving agent. The resolved