160707-37-9

Basic information

• Product Name: D-threo-α-Phenyl-
• Synonyms: D-threo-α-Phenyl-;D-threo-α-Phenyl-2-piperidineacetaMide
• CAS NO: 160707-37-9
• Molecular Formula: C₁₃H₁₈N₂O
• Molecular Weight: 218.29482
• Product Categories: Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 160707-37-9.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Methanol
• CAS DataBase Reference: D-threo-α-Phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: D-threo-α-Phenyl-(160707-37-9)
• EPA Substance Registry System: D-threo-α-Phenyl-(160707-37-9)

Safety Data

• Hazardous Substances Data: 160707-37-9(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Intermediate in the preparation of D-threo-Methylphenidate (Ritalin)

Upstream product

• 19395-39-2 (±)-erythro/threo-2-phenyl-2-(piperidin-2-yl)acetamide 
• 7251-52-7 2-phenyl-2-(pyridin-2-yl)acetamide 
• 5005-36-7 phenyl-pyridin-2-yl-acetonitrile 
• 109-09-1 2-chloropyridine 
• 741272-48-0 d-threo-[R(R*,R*)]-2-phenyl-2-piperidine-2-yl acetamide dibenzoyl-d-tartrate 
• 160707-38-0 l-threo-α-phenyl-α-piperidyl-(2)-acetamide 
• 160707-36-8 l-erythro-α-phenyl-α-piperidyl-(2)-acetamide 

Downstream Products

• 19262-68-1 dexmethylphenidate hydrochloride 
• 741705-70-4 d-threo-ritalinic acid hydrochloride 
• 40431-64-9 dexmethylphenidate 
• 851764-84-6 dexethylphenidate hydrochloride 

Relevant articles and documents

An Improved and Efficient Process for the Production of Highly Pure Dexmethylphenidate Hydrochloride

The present work describes an efficient and commercially viable process for the synthesis of dexmethylphenidate hydrochloride (1), a mild nervous system stimulant. The overall yield is 23% with ~99.9% purity (including seven chemical steps). Formation and control of possible impurities are also described in this report.

METHOD FOR THE PRODUCTION OF D-THREO-2-PHENYL-2-PIPERIDINE-2-YL ACETATES

Disclosed is a method for producing d-threo-[R(R*,R*)]-2-phenyl-2-piperidine-2-yl acetate and the acid addition salts thereof by converting d-threo-[R(R*,R*)]-2-phenyl-2-piperidine-2-yl ethanoic acid or an acid addition salt thereof into the corresponding

Processes and intermediates for resolving piperidyl acetamide stereoisomers

Processes and intermediates for preparing 2-substituted piperidines such as 2-substituted d-threo piperidines are provided, including processes and intermediates for resolution of piperidyl acetamide stereoisomers.