13832-70-7

Basic information

• Product Name: Octadecyl 3-hydroxy-11-oxoolean-12-en-29-oate
• Synonyms: Octadecyl3-hydroxy-11-oxoolean-12-en-29-oate;Stearylglycyrrhetate;Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, octadecyl ester, (3.beta.,20.beta.)-;RYL GLYCYRRHETINATE;steayl glycyrrhetinate;Glycyrrhetinic acid stearyl ester;Stearyl glycyrrhetinate;3β-Hydroxy-11-oxoolean-12-en-30-oic acid octadecyl ester
• CAS NO: 13832-70-7
• Molecular Formula: C₄₈H₈₂O₄
• Molecular Weight: 723.16228
• EINECS: 419-580-5
• Mol File: 13832-70-7.mol
• Article Data: 2

Chemical Properties

• Melting Point: 70-77 °C
• Boiling Point: 732.5°Cat760mmHg
• Flash Point: 198.8°C
• Appearance: /
• Density: 1.01g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.525
• PKA: 15.11±0.70(Predicted)
• Water Solubility: 9μg/L at 20℃
• BRN: 7612541
• CAS DataBase Reference: Octadecyl 3-hydroxy-11-oxoolean-12-en-29-oate(CAS DataBase Reference)
• NIST Chemistry Reference: Octadecyl 3-hydroxy-11-oxoolean-12-en-29-oate(13832-70-7)
• EPA Substance Registry System: Octadecyl 3-hydroxy-11-oxoolean-12-en-29-oate(13832-70-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 13832-70-7(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 13832-70-7 differently. You can refer to the following data:
1. stearyl glycyrrhetinate is anti-inflammatory and soothing. This is the ester of stearyl alcohol and glycyrrhetinic acid, where stearyl alcohol helps improve the penetration of the functional component, glycyrrhetinic acid.
2. Stearyl glycyrrhetinate can be used to prepare modified liposomes loaded with norcantharidin and 10-hydroxycamptothecin, which are used as drug delivery systems in cancer therapy.

General Description

Stearyl glycyrrhetinate is a stearic acid ester of glycyrrhetinic acid, generally used as a flavoring agent in commercially available cosmetic products.

InChI:InChI=1/C48H82O4/c1-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-33-52-42(51)45(5)30-29-44(4)31-32-47(7)36(37(44)35-45)34-38(49)41-46(6)27-26-40(50)43(2,3)39(46)25-28-48(41,47)8/h34,37,39-41,50H,9-33,35H2,1-8H3/t37-,39-,40-,41+,44+,45-,46-,47+,48+/m0/s1

Upstream product

• 112-92-5 1-octadecanol 
• 471-53-4 enoxolone 
• 135459-36-8 30-stearyl glycyrrhizin 
• 112-89-0 1-Bromooctadecane 

Downstream Products

• 1367192-03-7 O-(2-O-acetyl-3,4,6-tri-O-benzyl-α-D-mannopyranosyl) stearyl glycyrrhetinate 

Relevant articles and documents

Method for synthesizing octadecyl glycyrrhetinate

The invention discloses a method for synthesizing octadecyl glycyrrhetinate. The method comprises the following steps of: 1, synthesizing eutectic ionic liquid by taking choline chloride and urea as raw materials; 2, dissolving alkali in water to form an alkaline solution, mixing an alkaline solution with ethanol, and adding the mixture into the eutectic ionic liquid, adding glycyrrhetinic acid, and performing reacting to obtain glycyrrhetinic acid sodium salt; 3, adding bromo-octadecane into the sodium glycyrrhetinate, carrying out primary reflux reaction under a stirring condition, performing filtering, taking filtrate, cooling to room temperature, and performing filtering to obtain an octadecyl glycyrrhetinate crude product; and 4, sequentially carrying out secondary reflux refining, filtering and reduced pressure drying on the crude product of octadecyl glycyrrhetinate to obtain octadecyl glycyrrhetinate. The method has the advantages of mild reaction conditions, simpleness and convenience in purification treatment by taking ethanol as a solvent, low energy consumption and the high yield.