138344-06-6

Basic information

• Product Name: (2-tert-Butoxycarbonylamino-3-fluoro-phenyl)-acetic acid
• CAS NO: 138344-06-6
• Molecular Weight: 269.273
• Mol File: 138344-06-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2-tert-Butoxycarbonylamino-3-fluoro-phenyl)-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2-tert-Butoxycarbonylamino-3-fluoro-phenyl)-acetic acid(138344-06-6)
• EPA Substance Registry System: (2-tert-Butoxycarbonylamino-3-fluoro-phenyl)-acetic acid(138344-06-6)

Safety Data

• Hazardous Substances Data: 138344-06-6(Hazardous Substances Data)

Upstream product

• 98968-72-0 tert-butyl 2-fluorophenylcarbamate 
• 124-38-9 carbon dioxide 
• 138343-78-9 N-(tert-butoxycarbonyl)-2-fluoro-6-methylaniline 

Downstream Products

• 71294-03-6 7-fluoro-1,3-dihydro-indol-2-one 

Relevant articles and documents

Preparation of indoles and oxindoles from N-(tert-butoxycarbonyl)-2-alkylanilines

Treatment of dilithiated N-(tert-butoxycarbonyl)anilines 1 with dimethylformamide or carbon dioxide furnishes intermediates 3, 5, that are easily converted to N-(tert-butoxycarbonyl)indoles 4 and oxindoles (indol-2(3H)-ones, 7), respectively. Condensation of dilithiated 1 with N-methoxy-N-methylamides provides ketones 9 which are cyclized upon trifluoroacetic acid treatment to either 2-substituted 1-(tert-butoxycarbonyl)indoles 10 or 2-substituted indoles 11 depending on the reaction time. This general methodology has been applied to efficient synthesis of 1,2-alkyl-bridged indoles 12, 1,3,4,5-tetrahydrobenz[c,d]indole (16), 2a,3,4,5-tetrahydrobenz[c,d]indol-2(1H)-one (18), and 1-(tert-butoxycarbonyl)1H-pyrrolo[2,3-b]pyridine (21).