1383449-95-3

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 479252-05-6 ((2R,3R,4S,5R,6S)-3,4,5-Tris-benzyloxy-6-p-tolylsulfanyl-tetrahydro-pyran-2-yl)-methanol 
• 604-69-3 β-D-glucose pentaacetate 
• 106-45-6 para-thiocresol 
• 28244-94-2 p-tolyl-2,3,4,6-tetra-O-acetyl-1-thio-β-D-glucopyranoside 
• 819814-42-1 β-1-p-tolylthio-6-O-trityl-D-glucopyranose 
• 762287-68-3 p-tolyl-2,3,4-tri-O-benzyl-6-O-trityl-1-thio-β-D-glucopyranoside 

Downstream Products

• 1383450-14-3 1,2-di-O-myristoyl-3-O-(N-myristoyl-6'-amino-2',3',4'-tri-O-benzyl-6'-deoxy-α-D-glucopyranosyl)-sn-glycerol 
• 1383450-15-4 1,2-di-O-stearoyl-3-O-(N-stearoyl-6'-amino-2',3',4'-tri-O-benzyl-6'-deoxy-α-D-glucopyranosyl)-sn-glycerol 
• 1383450-16-5 1,2-di-O-isovaleryl-3-O-(N-isovaleryl-6'-amino-2',3',4'-tri-O-benzyl-6'-deoxy-α-D-glucopyranosyl)-sn-glycerol 
• 1383450-17-6 1,2-di-O-hydrocinnamoyl-3-O-(N-hydrocinnamoyl-6'-amino-2',3',4'-tri-O-benzyl-6'-deoxy-α-D-glucopyranosyl)-sn-glycerol 
• 1383450-25-6 1,2-di-O-hydrocinnamoyl-3-O-(N-hydrocinnamoyl-6'-amino-6'-deoxy-α-D-glucopyranosyl)-sn-glycerol 
• 1234307-07-3 1-O-(2,3,4-tri-O-benzyl-6-sulfo-α-D-glucopyranosyl)propane-1,3-diol sodium salt 
• 1383450-12-1 1,2-di-O-lauroyl-3-O-(N-lauroyl-6'-amino-2',3',4'-tri-O-benzyl-6'-deoxy-α-D-glucopyranosyl)-sn-glycerol 
• 1383450-10-9 1,2-di-O-octanoyl-3-O-(N-octanoyl-6'-amino-2',3',4'-tri-O-benzyl-6'-deoxy-α-D-glucopyranosyl)-sn-glycerol 
• 1383450-08-5 1,2-di-O-hexanoyl-3-O-(N-hexanoyl-6'-amino-2',3',4'-tri-O-benzyl-6'-deoxy-α-D-glucopyranosyl)-sn-glycerol 
• 1383450-05-2 3-O-(6'-amino-2',3',4'-tri-O-benzyl-6'-deoxy-α-D-glucopyranosyl)-sn-glycerol 
• 1383449-98-6 6-azido-2,3,4-tri-O-benzyl-6-deoxy-α-D-glucopyranosyl trichloroacetimidate 
• 1192755-07-9 1,2-di-O-palmitoyl-3-O-(N-palmitoyl-6'-amino-2',3',4'-tri-O-benzyl-6'-deoxy-α-D-glucopyranosyl)-sn-glycerol 
• 1192755-04-6 3-O-(6'-azido-2',3',4'-tri-O-benzyl-6'-deoxy-α-D-glucopyranosyl)-sn-glycerol 
• 1192755-03-5 3-O-(6'-azido-2',3',4'-tri-O-benzyl-6'-deoxy-α-D-glucopyranosyl)-1,2-O-isopropylidene-sn-glycerol 

Relevant academic research and scientific papers

Synthesis of glycoglycerolipid of 1,2-dipalmitoyl-3-(N-palmitoyl-6′- amino-6′-deoxy-α-D-glucosyl)-sn-glycerol and its analogues, inhibitors of human Myt1-kinase

A glycoglycerolipid 1a isolated from a marine alga showed inhibition to Myt1 kinase with IC50 of 0.12 μg/mL. We synthesized 1a and its seven analogues (1b-h) in an efficient method with high stereoselectivity. The process employed trichloroacetimidate donor 4b at low substrate concentration to achieve high α-selectivity (α/β = 33:1) in glycosylation reaction. The present synthesis provided various acyl derivatives required for the study on the structure-activity relationship later.

THIOALDOHEXOSE DERIVATIVE AND METHOD FOR PRODUCING SAME

PROBLEM TO BE SOLVED: To provide novel synthesis methods and novel intermediates of 3-(6-deoxysulfoaldohexose)-1-propanol derivatives. SOLUTION: The present invention provides a thioaldohexose derivative represented by the formula (III) where R is an optionally substituted alkyl group or an optionally substituted aryl group, R21, R31 and R41 are the same or different to represent a protective group of a hydroxy group, and -OR61 is a leaving group. SELECTED DRAWING: None COPYRIGHT: (C)2016,JPO&INPIT